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Jasplakinolide
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Catalog No. T11712Cas No. 102396-24-7
Alias NSC-613009, Jaspamide
Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin.
Jasplakinolide
😃Good
Catalog No. T11712Alias NSC-613009, JaspamideCas No. 102396-24-7
Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $998 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin. |
| In vitro | Jasplakinolide, at a concentration of 1 mM for 60 minutes, prompts the development of apical extensions rich in actin within fixed Toxoplasma gondii tachyzoites. It exhibits an IC50 of 35 nM against PC3 prostate carcinoma cells, underscoring its potent antiproliferative capability. Additionally, when introduced at 10 μM for 2 hours during mitosis, jasplakinolide leads to the formation of binucleated cells. This compound also triggers the production of F-actin-enriched apical extensions in Toxoplasma gondii tachyzoites, demonstrating its broad impact on cellular architecture.[1][2] |
| Alias | NSC-613009, Jaspamide |
| Molecular Weight | 709.67 |
| Formula | C36H45BrN4O6 |
| Cas No. | 102396-24-7 |
| Smiles | C(C=1C=2C(NC1Br)=CC=CC2)[C@@H]3C(=O)N[C@H](CC(=O)O[C@@H](C)C[C@@H](C)\C=C(\C)/C[C@H](C)C(=O)N[C@@H](C)C(=O)N3C)C4=CC=C(O)C=C4 |
| Relative Density. | 1.227g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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