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JDTic dihydrochloride

Catalog No. T11721LCas No. 785835-79-2

JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.

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Pack Size	Price	Availability
2 mg	$106	5 days
25 mg	$668	10-14 weeks
50 mg	$868	10-14 weeks
100 mg	$1,290	10-14 weeks

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Product Introduction

Bioactivity

Description

JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.

In vivo

JDTic administered intraperitoneally (i.p.) at a dose of 10 mg/kg effectively reduces alcohol self-administration, inhibits cue-induced alcohol seeking, and selectively antagonizes the effects of a kappa-opioid receptor (KOR) agonist 2 hours after treatment. At a higher dose (30 mg/kg) given intragastrically (i.g.), JDTic significantly prevents U50,488-induced diuresis in rats. When administered subcutaneously (s.c.) in doses ranging from 2.5 to 16 mg/kg, JDTic dose-dependently inhibits the antinociceptive effects of nicotine in the tail-flick test without affecting outcomes in the hot-plate test or altering body temperature in nicotine-injected mice. Additionally, a 3 mg/kg i.p. dose of JDTic effectively ameliorates anxiety-like behavior in a rat model of hangover anxiety.

Chemical Properties

Molecular Weight	538.55
Formula	C28H41Cl2N3O3
Cas No.	785835-79-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (185.68 mM)

H2O: 50 mg/mL (92.84 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.8568 mL	9.2842 mL	18.5684 mL	92.8419 mL
5 mM	0.3714 mL	1.8568 mL	3.7137 mL	18.5684 mL
10 mM	0.1857 mL	0.9284 mL	1.8568 mL	9.2842 mL
20 mM	0.0928 mL	0.4642 mL	0.9284 mL	4.6421 mL
50 mM	0.0371 mL	0.1857 mL	0.3714 mL	1.8568 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0186 mL	0.0928 mL	0.1857 mL	0.9284 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc