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JDTic dihydrochloride
Catalog No. T11721LCas No. 785835-79-2
JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.
JDTic dihydrochloride
Catalog No. T11721LCas No. 785835-79-2
JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $106 | 5 days | |
| 25 mg | $668 | 10-14 weeks | |
| 50 mg | $868 | 10-14 weeks | |
| 100 mg | $1,290 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488. |
| In vivo | JDTic administered intraperitoneally (i.p.) at a dose of 10 mg/kg effectively reduces alcohol self-administration, inhibits cue-induced alcohol seeking, and selectively antagonizes the effects of a kappa-opioid receptor (KOR) agonist 2 hours after treatment. At a higher dose (30 mg/kg) given intragastrically (i.g.), JDTic significantly prevents U50,488-induced diuresis in rats. When administered subcutaneously (s.c.) in doses ranging from 2.5 to 16 mg/kg, JDTic dose-dependently inhibits the antinociceptive effects of nicotine in the tail-flick test without affecting outcomes in the hot-plate test or altering body temperature in nicotine-injected mice. Additionally, a 3 mg/kg i.p. dose of JDTic effectively ameliorates anxiety-like behavior in a rat model of hangover anxiety. |
| Molecular Weight | 538.55 |
| Formula | C28H41Cl2N3O3 |
| Cas No. | 785835-79-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (185.68 mM), Sonication is recommended. H2O: 50 mg/mL (92.84 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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