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JTV-519 free base
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Catalog No. T11731Cas No. 145903-06-6
Alias K201 free base
JTV-519 free base (K201 free base), known for its antiarrhythmic and cardioprotective properties, acts as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and as a partial agonist of ryanodine receptors in striated muscle.
JTV-519 free base
😃Good
Catalog No. T11731Alias K201 free baseCas No. 145903-06-6
JTV-519 free base (K201 free base), known for its antiarrhythmic and cardioprotective properties, acts as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and as a partial agonist of ryanodine receptors in striated muscle.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 1-2 weeks | |
| 50 mg | $1,980 | 1-2 weeks | |
| 100 mg | $2,500 | 1-2 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | JTV-519 free base (K201 free base), known for its antiarrhythmic and cardioprotective properties, acts as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and as a partial agonist of ryanodine receptors in striated muscle. |
| In vitro | JTV-519 shows significant inhibition of Ca2+ movement due to annexin V, and 50% inhibition is achieved at 25 μM K201.JTV-519 inhibits inward Ca2+ movement into large unilamellar vesicles (LUV) caused by annexin V in a dose-dependent manner. In the presence of 50 nM annexin V and 400 μM Ca2+, 3 μM |
| In vivo | JTV-519 improves cardiac function in CLP mice, where the fractional shortening (FS) and ejection fraction (EF) are significantly increased as compared with CLP mice without JTV-519 treatment. |
| Alias | K201 free base |
| Molecular Weight | 424.6 |
| Formula | C25H32N2O2S |
| Cas No. | 145903-06-6 |
| Relative Density. | 1.153 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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