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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | Backorder | |
5 mg | $437 | Backorder | |
10 mg | $655 | Backorder | |
25 mg | $1,178 | Backorder | |
50 mg | $1,768 | Backorder | |
100 mg | $2,652 | Backorder | |
200 mg | $3,978 | Backorder |
Description | JTV-519 Formate is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA). JTV-519 Formate is also a partial agonist of ryanodine receptors in striated muscle. JTV-519 Formate exhibits antiarrhythmic and cardioprotective properties. |
In vitro | JTV-519 Formate was able to suppress spontaneous Ca2+ release in FK506-treated HEK-293 cells co-expressing RyR2 and FKBP12.6. Furthermore, K201 suppressed spontaneous Ca2+ release in HEK-293 cells expressing RyR2 alone and in cells co-expressing RyR2 and FKBP12.6 with the same potency. [2] |
Alias | JTV-519 Formate (145903-06-6 Free base) |
Molecular Weight | 470.62 |
Formula | C26H34N2O4S |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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