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JX237
JX237 functions as an inhibitor targeting the epithelial neutral amino acid transporter B 0 AT1 (SLC6A19), exhibiting a potency with an IC 50 of 31 nM. This compound primarily facilitates the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. The inhibition of B 0 AT1 by JX237 is instrumental in normalizing high levels of plasma amino acids found in rare metabolic amino acid disorders such as phenylketonuria and urea cycle disorders.
Catalog No. T89913Cas No. 1021125-90-5
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JX237
Catalog No. T89913Cas No. 1021125-90-5
JX237 functions as an inhibitor targeting the epithelial neutral amino acid transporter B 0 AT1 (SLC6A19), exhibiting a potency with an IC 50 of 31 nM. This compound primarily facilitates the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. The inhibition of B 0 AT1 by JX237 is instrumental in normalizing high levels of plasma amino acids found in rare metabolic amino acid disorders such as phenylketonuria and urea cycle disorders.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | JX237 functions as an inhibitor targeting the epithelial neutral amino acid transporter B 0 AT1 (SLC6A19), exhibiting a potency with an IC 50 of 31 nM. This compound primarily facilitates the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. The inhibition of B 0 AT1 by JX237 is instrumental in normalizing high levels of plasma amino acids found in rare metabolic amino acid disorders such as phenylketonuria and urea cycle disorders. |
| Molecular Weight | 271.15 |
| Formula | C11H15BrN2O |
| Cas No. | 1021125-90-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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