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JYL 1421

JYL 1421
JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).
Catalog No. T15634Cas No. 401907-26-4
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JYL 1421

Catalog No. T15634Alias SC 0030Cas No. 401907-26-4

JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$7676-8 weeks
50 mg$9976-8 weeks
100 mg$1,5706-8 weeks
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Product Introduction

Bioactivity
Description
JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).
Targets&IC50
TRPV1:8 nM
In vitro
JYL 1421(5 min) inhibits the capsaicin (330 nM)-evoked Ca2+ accumulation in a concentration-dependent manner. The inhibitory effect of the lowest concentration (5 nM) of JYL 1421 reaches the level of significance and 1 μM almost abolishes the response, only 3.1±0.65% of the first capsaicin-induced Ca2+ influx could be observed[1].
In vivo
Intravenous capsaicin injection at 1 and 2 μg/kg causes a temporary blood pressure drop of 47.4±4.7 and 59.6±4.2 mmHg (n=6), respectively. JYL 1421 at 0.4 and 1.6 mg/kg does not induce hypotension but inhibits the capsaicin-induced blood pressure drop in a dose-dependent manner, necessitating higher capsaicin doses to trigger reflex hypotension post-administration. Capsazepine up to 2 mg/kg does not significantly inhibit capsaicin-evoked hypotension. Capsaicin solution (50 μL, 10 μg/mL) instilled into the left eye of rats causes 12.9±1.3 wiping movements within 3 minutes. Pretreatment with JYL 1421 (0.4 or 1 mg/kg i.p.) does not significantly affect wiping behavior, but doses of 2-5 mg/kg reduce the movements dose-dependently with an ID50 value of 4.6 mg/kg. The mean arterial pressure of untreated rats is 109.9±4.2 mmHg (n=6)[1].
AliasSC 0030
Chemical Properties
Molecular Weight423.57
FormulaC20H26FN3O2S2
Cas No.401907-26-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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