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JYL 1421

Catalog No. T15634Cas No. 401907-26-4
Alias SC 0030

JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).

JYL 1421

JYL 1421

Catalog No. T15634Alias SC 0030Cas No. 401907-26-4
JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).
Pack SizePriceAvailabilityQuantity
25 mg$7676-8 weeks
50 mg$9976-8 weeks
100 mg$1,5706-8 weeks
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Product Introduction

Bioactivity
Description
JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).
Targets&IC50
TRPV1:8 nM
In vitro
JYL 1421(5 min) inhibits the capsaicin (330 nM)-evoked Ca2+ accumulation in a concentration-dependent manner. The inhibitory effect of the lowest concentration (5 nM) of JYL 1421 reaches the level of significance and 1 μM almost abolishes the response, only 3.1±0.65% of the first capsaicin-induced Ca2+ influx could be observed[1].
In vivo
Intravenous capsaicin injection at 1 and 2 μg/kg causes a temporary blood pressure drop of 47.4±4.7 and 59.6±4.2 mmHg (n=6), respectively. JYL 1421 at 0.4 and 1.6 mg/kg does not induce hypotension but inhibits the capsaicin-induced blood pressure drop in a dose-dependent manner, necessitating higher capsaicin doses to trigger reflex hypotension post-administration. Capsazepine up to 2 mg/kg does not significantly inhibit capsaicin-evoked hypotension. Capsaicin solution (50 μL, 10 μg/mL) instilled into the left eye of rats causes 12.9±1.3 wiping movements within 3 minutes. Pretreatment with JYL 1421 (0.4 or 1 mg/kg i.p.) does not significantly affect wiping behavior, but doses of 2-5 mg/kg reduce the movements dose-dependently with an ID50 value of 4.6 mg/kg. The mean arterial pressure of untreated rats is 109.9±4.2 mmHg (n=6)[1].
AliasSC 0030
Chemical Properties
Molecular Weight423.57
FormulaC20H26FN3O2S2
Cas No.401907-26-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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