Shopping Cart
- Remove All
Your shopping cart is currently empty
KF21213
Catalog No. T13745Cas No. 155271-17-3
KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.
KF21213
Catalog No. T13745Cas No. 155271-17-3
KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "KF21213"
Procaine
Vitamin H3, Spinocaine, Novocaine, Duracaine
T002959-46-1
Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.
- $30
Size
QTY
Procaine hydrochloride
Procaine HCl, Novocaine HCl
T080251-05-8
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
- $31
Size
QTY
Daminozide
Succinic Acid, DMASA, Aminozide
T37191596-84-5
Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.
- $42
Size
QTY
FY-21
T77583In house
FY-21 is a selective LSD1 inhibitor (IC50= 340 nM) that inhibits proliferation and colony formation of leukemia cells, decreases mRNA levels of the transcription factors HOXA9 and MEIS1, and can be used in the study of leukemia.
- $195
Size
QTY
AS8351
Cited
NSC51355, AS-8351, AS 8351
T4100796-42-9
AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
- $43
Size
QTY
CitedLSD1-IN-24
T678714734-59-2
LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases.
- $52
Size
QTY
GSK-J4 Cited
T31001373423-53-0In house
GSK-J4 (GSK J4 HCl) is a cell permeable prodrug of GSK-J1, a dual inhibitor of the H3K27me3/me2 demethylases JMJD3/KDM6B and UTX/KDM6A (IC50=8.6/6.6 μM). GSK-J4 induces endoplasmic reticulum stress-related apoptosis.
- $51
Size
QTY
CitedTranylcypromine (2-PCPA) hydrochloride
Tranylcypromine (2-PCPA) HCl, SKF-385 HCl
T10251986-47-6
Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and atypical depression.
- $39
Size
QTY
Eicosapentaenoic Acid
T536810417-94-4
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.
- $68
Size
QTY
Tranylcypromine hemisulfate Cited
Tranylcypromine Sulfate, Tranylcypromine (hemisulfate)
T794213492-01-8
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.
- $48
Size
QTY
CitedGSK-LSD1 dihydrochloride
GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)
T23152102933-95-7
GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B).
- $34
Size
QTY
Zavondemstat
TACH 101 free base, QC8222 free base
T701211851412-93-5In house
Zavondemstat (QC8222 free base) is a histone lysine demethylase 4 (KDM4) inhibitor with anticancer and antitumor activity for the study of triple-negative and breast cancers.
- $152
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors. |
| Targets&IC50 | A2A receptor:ki： 3.0 nM |
| In vitro | KF21213 shows a high affinity for the adenosine A2A receptors in vitro (Ki=3.0 nM) and a very low affinity for the A1 receptors (Ki>10,000 nM).KF21213 as a PET ligand for mapping adenosine A2A receptors in the central nervous system (CNS). |
| In vivo | Striatal uptake of [11C]KF21213 shows a gradual increase for the initial 15 minutes before declining, while its absorption by the cortex and cerebellum decreases swiftly post-injection, aligning with blood levels. As a result, the striatum to cortex and striatum to cerebellum uptake ratios escalate to 8.6±1.6 and 10.5±2.1 (N=4), respectively, within 60 minutes. Initially retained for 5 minutes, [11C]KF21213's striatal activity then diminishes over time, unlike [11C]KF18446, which drops quickly. Similarly, cerebellar activity for both ligands decreases rapidly. The striatum-to-cerebellum uptake ratio for [11C]KF21213 progressively increases to 2.4±0.5 (N=3) over 50-60 minutes, while for [11C]KF18446, it peaks within the first 10 minutes before stabilizing at 1.4±0.3 (N=3) between 25-35 minutes. |
| Molecular Weight | 354.4 |
| Formula | C19H22N4O3 |
| Cas No. | 155271-17-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy KF21213 | purchase KF21213 | KF21213 cost | order KF21213 | KF21213 chemical structure | KF21213 in vivo | KF21213 in vitro | KF21213 formula | KF21213 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.