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Kira8 Hydrochloride
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Kira8 Hydrochloride
Catalog No. T11762Cas No. 2250019-92-0
Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $793 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. |
| In vitro | Kira8 more effectively diminishes IRE1α-driven apoptosis in INS-1 cells compared to KIRA6 and additionally counteracts XBP1 splicing induced by GNF-2. It inhibits IRE1α oligomerization and significantly reduces IRE1α RNase activity targeting XBP1 and Ins2 RNAs. |
| In vivo | Male Ins2+/Akita mice are injected i.p. with KIRA8 (50 mg/kg; daily; for 35 days), significant reduction of hyperglycemia become apparent over several weeks. One week treatment of pre-diabetic NODs mice with Kira8 (50 mg/kg; i.p.; once a day) leads to significant reductions in islet XBP1 splicing and TXNIP mRNAs, and preserves Ins1/Ins2, BiP and MANF mRNAs. |
| Alias | AMG-18 Hydrochloride |
| Molecular Weight | 637.58 |
| Formula | C31H30Cl2N6O3S |
| Cas No. | 2250019-92-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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