Shopping Cart
- Remove All
Your shopping cart is currently empty
Kira8 Hydrochloride
Catalog No. T11762Cas No. 2250019-92-0
Alias AMG-18 Hydrochloride
Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
Kira8 Hydrochloride
Catalog No. T11762Alias AMG-18 HydrochlorideCas No. 2250019-92-0
Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $793 | 35 days |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Kira8 Hydrochloride"
Theobromine
3,7-Dimethylxanthine, 3, 7-Dimethylxanthine
T062583-67-0
Theobromine (3,7-Dimethylxanthine), a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.
- $30
Size
QTY
Doxofylline
Doxophylline
T048069975-86-6
Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies.
- $33
Size
QTY
Theophylline
Theo-24, 1,3-Dimethylxanthine
T108358-55-9
Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac, and central nervous system stimulant activities. It inhibits the 3', 5'-cyclic nucleotide phosphodiesterase that degrades cyclic AMP, thus potentiating the actions of agents that act through adenylyl cyclases and cyclic AMP.
- $41
Size
QTY
Inosine
Cited
NSC 20262, INO 495
T043758-63-9
Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.
- $29
Size
QTY
CitedTheophylline monohydrate
Quibron
T1083L5967-84-0
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Physiologically, this agent relaxes the bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates the cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm.
- $38
Size
QTY
Acefylline
Theophyllineacetic acid, Theophylline-7-acetic acid, Carboxymethyltheophylline, acetyloxytheophylline
T2205652-37-9
Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation Etanautine to help offset its stimulant effects
- $33
Size
QTY
Diphylline Cited
Dyphylline, Diprophylline
T0892479-18-5
Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles. Diphylline may also antagonize adenosinereceptors. Diphylline is used in the treatment of acute bronchial asthma, chronic bronchitis and emphysema.
- $60
Size
QTY
CitedAminophylline
Phyllocontin
T1681317-34-0
Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.
- $29
Size
QTY
Istradefylline
KW-6002
T6552155270-99-8
Istradefylline (KW-6002)(Ki of 2.2 nM) is a selective adenosine A2A receptor (A2AR) antagonist, which is under development in Phase 3 trails. It has been used in trials studying the treatment and basic science of Drug Abuse, Sleep Disorder, Hepatic Impairment, Parkinson's Disease, and Restless Legs Syndrome, among others.
- $35
Size
QTY
Adenosine antagonist-1
T10248431040-19-6In house
Adenosine antagonist-1 acts as an adenosine A3 receptor (AA3R) antagonist.
- $248
Size
QTY
FK-453
FK453, FK 453
T27323121524-18-3In house
FK-453 is a potent antagonist of non-xanthine adenosine A1 receptor with diuretic and renal vasodilatory activity.
- $250
Size
QTY
Nitrobenzylthioinosine
Cited
NBMPR
T855138048-32-7
Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.
- $40
Size
QTY
CitedContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. |
| Targets&IC50 | IRE1α:, IRE1α RNase:5.9 nM |
| In vitro | Kira8 more effectively diminishes IRE1α-driven apoptosis in INS-1 cells compared to KIRA6 and additionally counteracts XBP1 splicing induced by GNF-2. It inhibits IRE1α oligomerization and significantly reduces IRE1α RNase activity targeting XBP1 and Ins2 RNAs. |
| In vivo | Male Ins2+/Akita mice are injected i.p. with KIRA8 (50 mg/kg; daily; for 35 days), significant reduction of hyperglycemia become apparent over several weeks. One week treatment of pre-diabetic NODs mice with Kira8 (50 mg/kg; i.p.; once a day) leads to significant reductions in islet XBP1 splicing and TXNIP mRNAs, and preserves Ins1/Ins2, BiP and MANF mRNAs. |
| Alias | AMG-18 Hydrochloride |
| Molecular Weight | 637.58 |
| Formula | C31H30Cl2N6O3S |
| Cas No. | 2250019-92-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Kira8 Hydrochloride | purchase Kira8 Hydrochloride | Kira8 Hydrochloride cost | order Kira8 Hydrochloride | Kira8 Hydrochloride chemical structure | Kira8 Hydrochloride in vivo | Kira8 Hydrochloride in vitro | Kira8 Hydrochloride formula | Kira8 Hydrochloride molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.