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KTC1101

🥰Excellent
Catalog No. T89831Cas No. 2764833-47-6
Alias KTC 1101

KTC1101 is an oral-active, pan-PI3K inhibitor targeting tumor cell proliferation and tumor microenvironment, with anti-proliferative and anti-tumor activity, reducing downstream AKT and mTOR phosphorylation.

KTC1101

KTC1101

🥰Excellent
Catalog No. T89831Alias KTC 1101Cas No. 2764833-47-6
KTC1101 is an oral-active, pan-PI3K inhibitor targeting tumor cell proliferation and tumor microenvironment, with anti-proliferative and anti-tumor activity, reducing downstream AKT and mTOR phosphorylation.
Pack SizePriceAvailabilityQuantity
1 mg$73 In Stock
5 mg$160 In Stock
10 mg$260 In Stock
25 mg$522 In Stock
50 mg$843 In Stock
100 mg$1,350 In Stock
1 mL x 10 mM (in DMSO)$160 In Stock
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Product Introduction

Bioactivity
Description
KTC1101 is an oral-active, pan-PI3K inhibitor targeting tumor cell proliferation and tumor microenvironment, with anti-proliferative and anti-tumor activity, reducing downstream AKT and mTOR phosphorylation.
Targets&IC50
PI3Kβ:36.29 nM, PI3Kα:3.72 nM, PI3Kδ:1.22 nM, PI3Kγ:17.09 nM
In vitro
The IC50 values of KTC1101 for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ were 3.72 nM, 36.29 nM, 1.22 nM and 17.09 nM, respectively.
KTC1101 effectively inhibited the PI3K signaling pathway, and the phosphorylation of PI3K downstream effector AKT and mTOR was decreased. [1]
In vivo
In mice, KTC1101 (100 mg/kg) has good oral effect, Tmax is 0.67 h, Cmax is 1.66 μg/mL, AUC0-t is 9.33 μg/mL*h.
KTC1101 (100 mg/kg) showed favorable tumor inhibition in mice in four tumor models tested (PC3, CAL33, and HSC2). [1]
AliasKTC 1101
Chemical Properties
Molecular Weight476.48
FormulaC21H26F2N8O3
Cas No.2764833-47-6
SmilesFC(F)C1=NC=2C(OC)=CC(N)=CC2N1C=3N=C(N=C(N3)N4CCOCCC4)N5CCOCC5
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20.00 mg/mL (41.97 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0987 mL10.4936 mL20.9872 mL104.9362 mL
5 mM0.4197 mL2.0987 mL4.1974 mL20.9872 mL
10 mM0.2099 mL1.0494 mL2.0987 mL10.4936 mL
20 mM0.1049 mL0.5247 mL1.0494 mL5.2468 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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