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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $158 | In Stock | |
5 mg | $396 | In Stock | |
10 mg | $589 | In Stock | |
25 mg | $943 | In Stock | |
50 mg | $1,280 | In Stock | |
100 mg | $1,720 | In Stock | |
1 mL x 10 mM (in DMSO) | $445 | In Stock |
Description | L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist and benzolactam derivative, known for reversing glucocorticoid-induced inhibition of GH secretion. L-692429 exhibits high affinity for the G protein-coupled receptor and is useful in studying acromegaly and obesity. |
Targets&IC50 | intracellular calcium:26 nM (EC50), BRET:58 nM (EC50), CREB:60 nM (EC50), Serum-responsive element activity:63 nM (EC50), inositol phosphate (IP) turnover:47 nM (EC50) |
In vitro | L-692429, a chemical compound, activates various cellular mechanisms, including intracellular calcium release, inositol phosphate (IP) turnover, cAMP-responsive element binding protein (CREB) activity, serum-responsive element activity, and bioluminescence resonance energy transfer (BRET) activity, with EC50 values of 26 nM, 47 nM, 60 nM, 63 nM, and 58 nM, respectively[2]. In experiments involving HeLa-T4 cells, those transiently expressing flag epitope-tagged growth hormone secretagogue (GHS) receptor and treated with L-692429 show a measurable increase in intracellular calcium, as detected by fluorometry using fluo-3/AM calcium indicator dye. This response is absent in untransfected HeLa-T4 cells, indicating the specificity of L-692429 for GHS receptor-expressing cells. Moreover, L-692429 treatment significantly enhances luciferase activity in these cells, suggesting that GHS receptor activation triggers the MAPK pathway[1]. |
In vivo | In anesthetized Wistar rats, L-756867 dose-dependently suppresses GH secretion stimulated by L-692429 (100 μg/kg), with complete inhibition achieved at an intravenous dose of 100 μg/kg of L-756867[3]. |
Alias | MK-0751 |
Molecular Weight | 509.614 |
Formula | C29H31N7O2 |
Cas No. | 145455-23-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (78.49 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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