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Triamterene
🥰Excellent
Catalog No. T0843Cas No. 396-01-0
Alias SKF8542, Ademine
Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.
Triamterene
🥰Excellent
Purity: 99.49%
Catalog No. T0843Alias SKF8542, AdemineCas No. 396-01-0
Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $37 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $59 | In Stock |
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Purity:99.49%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner. |
| Targets&IC50 | ENaC:4.5 μM, ENaCαS583:23.9 μM |
| In vitro | Triamterene's 4'-hydroxylation in the human body appears to be mediated solely by CYP1A2. The inhibition or induction of CYP1A2 can alter the temporal profile of both Triamterene and its active phase II metabolites. |
| In vivo | Triamterene inhibits epithelial sodium channels in the distal convoluted tubule and collecting duct principal cells, leading to a reduction in total sodium reabsorption by 1-2%. By impeding sodium reabsorption, triamterene also diminishes potassium secretion. Normally, potassium secretion is driven by the electrochemical gradient produced by sodium reabsorption. As sodium is reabsorbed, a negative potential is left in the tubular lumen while a positive potential is created in the principal cells. This electrical potential promotes potassium excretion through apical potassium channels. |
| Alias | SKF8542, Ademine |
| Molecular Weight | 253.26 |
| Formula | C12H11N7 |
| Cas No. | 396-01-0 |
| Smiles | Nc1nc(N)c2nc(c(N)nc2n1)-c1ccccc1 |
| Relative Density. | 1.502 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.33 mg/mL (13.16 mM), Sonication is recommended.  Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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