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L524-0366

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Purity:96.31%

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COA HNMR HPLC

L524-0366

Catalog No. T8570Cas No. 951612-19-4

L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor.

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Pack Size	Price	Availability
1 mg	$134	In Stock
2 mg	$198	In Stock
5 mg	$297	In Stock
10 mg	$453	In Stock
25 mg	$769	In Stock
50 mg	$995	In Stock
100 mg	$1,450	In Stock
1 mL x 10 mM (in DMSO)	$297	In Stock

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Product Introduction

Bioactivity

Description	L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor.
In vitro	L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling. Finally, Fn14 expression was increased in mouse following TAC and in human failing hearts.
Cell Research	Wild type (WT) and Fn14 knock out (Fn14-/-) mice were subjected to pressure overload [transaortic constriction (TAC)] for 1 or 6 weeks. A subset of WT TAC animals were treated with the Fn14 antagonist L524-0366. Cardiac function was measured by echocardiography. Cardiac fibrosis and macrophage infiltration were quantified using immunohistochemistry and flow cytometry, respectively. Cardiac fibroblasts were isolated for quantifying TWEAK-induced chemokine release.
Alias	[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone

Chemical Properties

Molecular Weight	308.79
Formula	C13H13ClN4OS
Cas No.	951612-19-4

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

5% DMSO+95% Corn oil: 1 mg/mL, Sonication is recommended.

DMSO: 25 mg/ml (80.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2384 mL	16.1922 mL	32.3845 mL	161.9223 mL
5 mM	0.6477 mL	3.2384 mL	6.4769 mL	32.3845 mL
10 mM	0.3238 mL	1.6192 mL	3.2384 mL	16.1922 mL
20 mM	0.1619 mL	0.8096 mL	1.6192 mL	8.0961 mL
50 mM	0.0648 mL	0.3238 mL	0.6477 mL	3.2384 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

L524 0366L524-0366L5240366L-524-0366