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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $134 | In Stock | |
2 mg | $198 | In Stock | |
5 mg | $297 | In Stock | |
10 mg | $453 | In Stock | |
25 mg | $769 | In Stock | |
50 mg | $995 | In Stock | |
100 mg | $1,450 | In Stock | |
1 mL x 10 mM (in DMSO) | $297 | In Stock |
Description | L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor. |
In vitro | L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling. Finally, Fn14 expression was increased in mouse following TAC and in human failing hearts. |
Cell Research | Wild type (WT) and Fn14 knock out (Fn14-/-) mice were subjected to pressure overload [transaortic constriction (TAC)] for 1 or 6 weeks. A subset of WT TAC animals were treated with the Fn14 antagonist L524-0366. Cardiac function was measured by echocardiography. Cardiac fibrosis and macrophage infiltration were quantified using immunohistochemistry and flow cytometry, respectively. Cardiac fibroblasts were isolated for quantifying TWEAK-induced chemokine release. |
Alias | [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone |
Molecular Weight | 308.79 |
Formula | C13H13ClN4OS |
Cas No. | 951612-19-4 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | 5% DMSO+95% Corn oil: 1 mg/mL, Sonication is recommended. ![]() DMSO: 25 mg/ml (80.96 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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