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Lepzacitinib

🥰Excellent
Catalog No. T78207Cas No. 2321488-47-3
Alias ATI-1777, ATI1777

Lepzacitinib is a selective, small molecule JAK1/3 inhibitor used for the treatment of atopic dermatitis and other skin diseases. As a Janus kinase inhibitor, it reduces the inflammatory response.

Lepzacitinib

Lepzacitinib

🥰Excellent
Catalog No. T78207Alias ATI-1777, ATI1777Cas No. 2321488-47-3
Lepzacitinib is a selective, small molecule JAK1/3 inhibitor used for the treatment of atopic dermatitis and other skin diseases. As a Janus kinase inhibitor, it reduces the inflammatory response.
Pack SizePriceAvailabilityQuantity
1 mg$66 In Stock
5 mg$153 In Stock
10 mg$225 In Stock
25 mg$378 In Stock
50 mg$562 In Stock
100 mg$790 In Stock
200 mg$1,120 In Stock
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Product Introduction

Bioactivity
Description
Lepzacitinib is a selective, small molecule JAK1/3 inhibitor used for the treatment of atopic dermatitis and other skin diseases. As a Janus kinase inhibitor, it reduces the inflammatory response.
AliasATI-1777, ATI1777
Chemical Properties
Molecular Weight355.39
FormulaC18H21N5O3
Cas No.2321488-47-3
SmilesN(C1=C2C(=NC=C1C(OCC)=O)NC=C2)[C@H]3CN(C(CC#N)=O)CCC3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (225.1 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8138 mL14.0691 mL28.1381 mL140.6905 mL
5 mM0.5628 mL2.8138 mL5.6276 mL28.1381 mL
10 mM0.2814 mL1.4069 mL2.8138 mL14.0691 mL
20 mM0.1407 mL0.7035 mL1.4069 mL7.0345 mL
50 mM0.0563 mL0.2814 mL0.5628 mL2.8138 mL
100 mM0.0281 mL0.1407 mL0.2814 mL1.4069 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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