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Losatuxizumab
🥰Excellent
Catalog No. T77073Cas No. 1801544-27-3
Alias ABT-806, ABT806
Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody that is a naked antibody to the ADC compound Losatuxizumab vedotin, with potential anti-tumor activity for the study of advanced malignant solid tumors.
Losatuxizumab
Losatuxizumab
🥰Excellent
Purity: 95%
Catalog No. T77073Alias ABT-806, ABT806Cas No. 1801544-27-3
Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody that is a naked antibody to the ADC compound Losatuxizumab vedotin, with potential anti-tumor activity for the study of advanced malignant solid tumors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 187 € | In Stock | |
| 5 mg | 490 € | In Stock | |
| 10 mg | 786 € | In Stock | |
| 25 mg | 1.168 € | In Stock | |
| 50 mg | 1.567 € | In Stock |
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Concentration:13.22 mg/mL
Purity:95%
Contact us for more batch information
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Product Introduction
Bioactivity
Chemical Properties
| Description | Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody that is a naked antibody to the ADC compound Losatuxizumab vedotin, with potential anti-tumor activity for the study of advanced malignant solid tumors. |
| Targets&IC50 | EGFR vIII:0.12 nM (EC50), EGFR (WT):0.96 nM (EC50), EGFR (1-501):0.66 nM (EC50), EGFR phosphorylation:1.2 nM |
| In vitro | Losatuxizumab (ABT-806) binds EGFR with EC50 values of 0.96 nM for EGFR wild type, 0.09 nM for EGFR(C271A,C283A), 0.12 nM for EGFR(vIII), and 0.66 nM for EGFR(1-501).[1] Losatuxizumab inhibited EGF-induced EGFR phosphorylation with an IC50 of 1.2 nM in the NR6 huEGFR(C271A,C283A) cell line.[2] |
| In vivo | Losatuxizumab exhibits antitumor activity against multiple wild-type EGFR-expressing squamous cell carcinoma xenograft models. [1] Losatuxizumab (40 mg/kg, intraperitoneal) significantly delayed the growth of U87MGde2-7 tumors in mice. [1] Losatuxizumab (10 and 40 mg/kg, intraperitoneal) prolonged survival in a patient-derived xenograft glioblastoma (PDX GBM) model (SN0207 tumors) while decreasing pEGFR levels in tumor tissue. [1] |
| Alias | ABT-806, ABT806 |
| Cas No. | 1801544-27-3 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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