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LY2794193
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Catalog No. T15807Cas No. 2173037-97-1
Alias LY 2794193
LY2794193, a potent and selective mGlu3 (metabotropic glutamate 3) receptor agonist, Ki=0.927 nM, EC50=0.47 nM, reduces akathisia seizures and depressive-like behaviors and increases GAT1, GLAST and GLT-1 protein levels in rats.
LY2794193
😃Good
Purity: 98.15%
Catalog No. T15807Alias LY 2794193Cas No. 2173037-97-1
LY2794193, a potent and selective mGlu3 (metabotropic glutamate 3) receptor agonist, Ki=0.927 nM, EC50=0.47 nM, reduces akathisia seizures and depressive-like behaviors and increases GAT1, GLAST and GLT-1 protein levels in rats.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $523 | In Stock | |
| 25 mg | $1,810 | 10-14 weeks | |
| 50 mg | $2,360 | 10-14 weeks | |
| 100 mg | $3,270 | 10-14 weeks |
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Purity:98.15%
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Product Introduction
Bioactivity
Chemical Properties
| Description | LY2794193, a potent and selective mGlu3 (metabotropic glutamate 3) receptor agonist, Ki=0.927 nM, EC50=0.47 nM, reduces akathisia seizures and depressive-like behaviors and increases GAT1, GLAST and GLT-1 protein levels in rats. |
| Targets&IC50 | mGluR2:412 (ki), mGluR3:0.927 nM (ki), mGluR3:0.47 nM (EC50), mGluR2:47.5 (EC50) |
| In vitro | When its agonist responses were examined in cells co-expressing a promiscuous G protein (Gαq), LY2794193 exhibited agonist activity against both hmGlu3 (EC50 value of 11.6 nM) and hmGlu2 (EC50 value of 277 nM).[1] |
| In vivo | Methods: Two doses of LY2794193 (0.1, 0.3, and 1 mg/kg, sc) and LY2794193 (1, 3, and 10 mg/kg, sc) were administered to rats; the first study employed dose levels, while the second evaluated higher doses; in each study, plasma and cerebrospinal fluid (CSF) levels were determined 1 h after LY2794193 administration. Results: Plasma and CSF levels of LY2794193 were observed at all dose levels, and a linear increase in each compartment with increasing dose was observed. The fraction of LY2794193 partitioning into the CSF was both low and highly consistent across dose levels, with a CSF to plasma ratio of 1% calculated over a 100-fold concentration range. [1] |
| Alias | LY 2794193 |
| Molecular Weight | 334.32 |
| Formula | C16H18N2O6 |
| Cas No. | 2173037-97-1 |
| Smiles | C(O)(=O)[C@H]1[C@]2([C@@]1([C@@](C(O)=O)(N)C[C@@H]2NC(=O)C3=CC(OC)=CC=C3)[H])[H] |
| Relative Density. | 1.50 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 1 mg/mL (2.99 mM), adjust pH to 14 with NaOH DMSO: 180 mg/mL (538.41 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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