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LY341495

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Catalog No. T15816Cas No. 201943-63-7

LY341495 is a potent metabotropic glutamate receptor antagonist that exhibits high activity against a wide range of glutamate receptor subtypes and can be used for the study of neurological disorders.

LY341495

LY341495

🥰Excellent
Purity: 99.37%
Catalog No. T15816Cas No. 201943-63-7
LY341495 is a potent metabotropic glutamate receptor antagonist that exhibits high activity against a wide range of glutamate receptor subtypes and can be used for the study of neurological disorders.
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1 mg$39In Stock
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Purity:99.37%
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Product Introduction

Bioactivity
Description
LY341495 is a potent metabotropic glutamate receptor antagonist that exhibits high activity against a wide range of glutamate receptor subtypes and can be used for the study of neurological disorders.
Targets&IC50
mGluR8:170 nM, mGluR1a:7.8 μM, mGluR2:21 nM, mGluR7:990 nM, 21 nM:mGluR3
In vivo
Acute administration of LY341495 (3.0 mg/kg) reduces levels of pAkt and pGSK-3, but repeated administration (3.0 mg/kg) is required to decrease β-catenin levels[2].
Chemical Properties
Molecular Weight353.37
FormulaC20H19NO5
Cas No.201943-63-7
SmilesN[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Relative Density.1.432 g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 5 mg/mL (14.15 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8299 mL14.1495 mL28.2990 mL141.4948 mL
5 mM0.5660 mL2.8299 mL5.6598 mL28.2990 mL
10 mM0.2830 mL1.4149 mL2.8299 mL14.1495 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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