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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $199 | In Stock | |
1 mL x 10 mM (in DMSO) | $376 | 6-8 weeks |
Description | M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research. |
Targets&IC50 | MRK:<125 nM |
In vitro | The osmotic pumps were filled with a solution of 0.05 mg/ml M443 or vehicle [0.01% DMSO in PBS], and implanted into the backs of animals. The results showed that treatment with M443 alone extended the survival of mice by 5.5 days. |
In vivo | As a time-dependent irreversible MRK inhibitor, M443 (500 nM) significantly inhibits the activation of MRK, Chk2, and p38 stimulated by IR. |
Molecular Weight | 589.61 |
Formula | C31H30F3N7O2 |
Cas No. | 1820684-31-8 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (50.88 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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