Shopping Cart
- Remove All
Your shopping cart is currently empty
Masofaniten
Catalog No. T72985Cas No. 2416716-62-4
Alias EPI-7386, EPI7386, Androgen receptor-IN-2
Masofaniten (EPI-7386) is an orally active androgen receptor (AR) inhibitor with antitumor activity for the study of prostate and breast cancers.
Masofaniten
Catalog No. T72985Alias EPI-7386, EPI7386, Androgen receptor-IN-2Cas No. 2416716-62-4
Masofaniten (EPI-7386) is an orally active androgen receptor (AR) inhibitor with antitumor activity for the study of prostate and breast cancers.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,620 | 7-10 days | |
| 50 mg | $2,110 | 7-10 days | |
| 100 mg | $3,150 | 7-10 days |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Masofaniten"
Flutamide
Cited
SCH 13521
T048913311-84-7
Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
- $30
Size
QTY
CitedS-23
S23, (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide
T207891010396-29-8
S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.
- $39
Size
QTY
Allura Red AC
FD&C RED NO. 40, CI 16035, Allura Red
TN137025956-17-6
Allura Red AC (CI 16035) is a very important food azo dye used in the food, pharmaceutical, paper, cosmetic and textile industries.Allura Red AC promotes susceptibility to experimental colitis via mouse intestinal serotonin.
- $50
Size
QTY
Dehydroisoandrosterone 3-acetate
Prasterone acetate, DHEA acetate, Dehydroepiandrosterone acetate, Dehydroepiandrosterone 3-acetate, androstenolone acetate
T0856853-23-6
Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.
- $41
Size
QTY
Sunset Yellow FCF
Sunset yellow, Orange Yellow S, Food Yellow 3, CI 15985
TN22452783-94-0
Sunset Yellow FCF (Sunset yellow) is an orange azo dye with pH-dependent absorbance.Sunset Yellow FCF is used in food, cosmetics and pharmaceuticals.It is used as a colorant food additive in many food products.They may be cytotoxic and genotoxic, so care must be taken when using these materials as food additives.
- $41
Size
QTY
Octinoxate
Octyl methoxycinnamate, Octyl 4-methoxycinnamate, ethylhexyl methoxycinnamate, 2-Ethylhexyl 4-methoxycinnamate
T00735466-77-3
Octyl 4-methoxycinnamate is an organic compound that absorbs UV-B rays from the sun, protects the skin from damage, and can also be used to minimize the appearance of scars and is commonly used in cosmetics such as sunscreens and lipsticks.Octinoxate has androgenic and estrogenic effects.
- $41
Size
QTY
Ostarine
MK-2866, GTX-024, Enobosarm
T2408841205-47-8
Ostarine (MK-2866) is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone's action, this agent may increase lean body mass, thereby ameliorating muscle wasting in the hypermetabolic state of cancer cachexia.
- $36
Size
QTY
Bicalutamide
ICI-176334
T038090357-06-5
Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.
- $32
Size
QTY
Bavdegalutamide Cited
ARV-110
T222632222112-77-6
Bavdegalutamide (ARV-110) is an oral protein degrader that specifically binds to AR and mediates its degradation. Bavdegalutamide can degrade clinically relevant mutant AR proteins, maintain activity in a high androgen environment, and has an acceptable safety profile.
- $85
Size
QTY
CitedSK33
T129281928724-23-5
SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.
- $74
Size
QTY
2,2,5,7,8-Pentamethyl-6-Chromanol Cited
PMC
T14008950-99-2
2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the antioxidant component of vitamin E (α-tocopherol) and exhibits significant androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.
- $53
Size
QTY
Cited2-hydroxy Flutamide
T769052806-53-8
2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer
- $47
Size
QTY
Select Batch
Purity:98.66%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Masofaniten (EPI-7386) is an orally active androgen receptor (AR) inhibitor with antitumor activity for the study of prostate and breast cancers. |
| Targets&IC50 | Androgen receptor:535 nM, LNCaP cells:0.44 μM, LNCaP95 cells:3.78 μM |
| In vitro | In the androgen-induced PSA-luciferase assay, Masofaniten effectively inhibited androgen binding to the androgen receptor with an IC50 value of 535 nM. In LNCaP and LNCaP95 cells, Masofaniten showed an inhibitory effect on cell proliferation with IC50 values of 0.44 μM and 3.78 μM, respectively. In addition, Masofaniten showed good metabolic stability in liver microsomes with a half-life of more than 120 min, while the half-life in hepatocytes was more than 360 min. [1] |
| In vivo | Masofaniten was able to partially inhibit tumor growth in NCG mice bearing LNCaP tumors after oral administration at a dose of 60 mg/kg. In male CD-1 mice, a single oral administration of Masofaniten at 5 mg/kg exhibited a half-life of 8.1 hours, a maximum concentration (Cmax) of 2673.3 ng/mL, and a bioavailability (F (%)) of 33.6. [1] |
| Alias | EPI-7386, EPI7386, Androgen receptor-IN-2 |
| Molecular Weight | 535.44 |
| Formula | C24H24Cl2N4O4S |
| Cas No. | 2416716-62-4 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (74.7 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Masofaniten | purchase Masofaniten | Masofaniten cost | order Masofaniten | Masofaniten chemical structure | Masofaniten in vivo | Masofaniten in vitro | Masofaniten formula | Masofaniten molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.