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Mc-MMAD
Catalog No. T18311Cas No. 1401963-15-2
Mc-MMAD, a drug-linker conjugate for antibody-drug conjugates (ADCs), incorporates the protective group maleimidocaproyl (Mc) conjugated to monomethyl auristatin D (MMAD), a potent inhibitor of tubulin.
Mc-MMAD
Catalog No. T18311Cas No. 1401963-15-2
Mc-MMAD, a drug-linker conjugate for antibody-drug conjugates (ADCs), incorporates the protective group maleimidocaproyl (Mc) conjugated to monomethyl auristatin D (MMAD), a potent inhibitor of tubulin.
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| 100 mg | Inquiry | Backorder | |
| 500 mg | Inquiry | Backorder |
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Mc-MMAE
Cited
Maleimidocaproyl-monomethylauristatin E
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Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.
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McMMAF
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McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC linker), which is ready to conjugate to antibody or other proteins or biopolymers. Mafodotin is a useful agent for make antibody drug conjugate (ADC) for targeted drug delivery.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Mc-MMAD, a drug-linker conjugate for antibody-drug conjugates (ADCs), incorporates the protective group maleimidocaproyl (Mc) conjugated to monomethyl auristatin D (MMAD), a potent inhibitor of tubulin. |
| Molecular Weight | 964.26 |
| Formula | C51H77N7O9S |
| Cas No. | 1401963-15-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (103.71 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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