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MC-Gly-Gly-Phe-Gly-GABA-Exatecan
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Catalog No. T87847Cas No. 1599439-52-7
MC-Gly-Gly-Phe-Gly-GABA-Exatecan, functioning both as an ADC linker agent and a topoisomerase inhibitor (Exatecan), displays cytotoxic and antitumor properties in vitro and in vivo [1] [2]. It specifically targets various antibodies and boasts an IC 50 of 22 μM.
MC-Gly-Gly-Phe-Gly-GABA-Exatecan
😃Good
Catalog No. T87847Cas No. 1599439-52-7
MC-Gly-Gly-Phe-Gly-GABA-Exatecan, functioning both as an ADC linker agent and a topoisomerase inhibitor (Exatecan), displays cytotoxic and antitumor properties in vitro and in vivo [1] [2]. It specifically targets various antibodies and boasts an IC 50 of 22 μM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MC-Gly-Gly-Phe-Gly-GABA-Exatecan, functioning both as an ADC linker agent and a topoisomerase inhibitor (Exatecan), displays cytotoxic and antitumor properties in vitro and in vivo [1] [2]. It specifically targets various antibodies and boasts an IC 50 of 22 μM. |
| In vitro | MC-Gly-Gly-Phe-Gly-GABA-Exatecan (0-10 μM) exhibits cytotoxicity by targeting antibodies CD30, CD33, CD70, and B7-H3 in the cell lines SR (CD30 positive), HL60 (CD33 positive), U251 (CD70 positive), and Calu-6 (B7-H3 positive) [2]. Cell Viability Assay [2] was conducted using SR, HL60, U251, and Calu-6 with a concentration range of 0-10 μM over 6 days, resulting in reduced cell viability. |
| In vivo | The compound MC-Gly-Gly-Phe-Gly-GABA-Exatecan, administered intravenously at 10 mg/kg once weekly for two weeks, demonstrates antitumor activity in A375 xenograft mice, resulting in inhibited tumor growth and induced tumor regression [2]. |
| Molecular Weight | 1032.08 |
| Formula | C53H58FN9O12 |
| Cas No. | 1599439-52-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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