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MD-222
Catalog No. T37041Cas No. 2136246-72-3
MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2].
MD-222
Catalog No. T37041Cas No. 2136246-72-3
MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $789 | Backorder | |
| 10 mg | $1,360 | Backorder | |
| 25 mg | $2,860 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2]. |
| In vitro | MD-222 (1-30 nM; 1-2 hours) treatment effectively reduces MDM2 protein levels and increases p53 levels in a time- and dose-dependent manner in RS4;11 and RS4;11/IRMI-2 cells[1]. MD-222 (30-100 nM; 6 hours) increases the expression of p53-targeted genes, including MDM2, CDKN1A, and PUMA in RS4;11 cells, indicating strong p53 activation[2]. MD-222 (4 days) inhibits cell growth in RS4;11 cells with an IC50 of 5.5 nM, but shows no effect on RS4;11/IRMI-2, MDA-MB-231, and MDA-MB-468 cells[1]. |
| Molecular Weight | 893.84 |
| Formula | C48H47Cl2FN6O6 |
| Cas No. | 2136246-72-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 200 mg/mL (223.76 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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