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MD-222

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MD-222

Catalog No. T37041Cas No. 2136246-72-3

MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2].

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Pack Size	Price	Availability
5 mg	$789	Backorder
10 mg	$1,360	Backorder
25 mg	$2,860	Backorder

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Product Introduction

Bioactivity

Description

In vitro

MD-222 (1-30 nM; 1-2 hours) treatment effectively reduces MDM2 protein levels and increases p53 levels in a time- and dose-dependent manner in RS4;11 and RS4;11/IRMI-2 cells[1]. MD-222 (30-100 nM; 6 hours) increases the expression of p53-targeted genes, including MDM2, CDKN1A, and PUMA in RS4;11 cells, indicating strong p53 activation[2]. MD-222 (4 days) inhibits cell growth in RS4;11 cells with an IC50 of 5.5 nM, but shows no effect on RS4;11/IRMI-2, MDA-MB-231, and MDA-MB-468 cells[1].

Chemical Properties

Molecular Weight	893.84
Formula	C48H47Cl2FN6O6
Cas No.	2136246-72-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 200 mg/mL (223.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1188 mL	5.5938 mL	11.1877 mL	55.9384 mL
5 mM	0.2238 mL	1.1188 mL	2.2375 mL	11.1877 mL
10 mM	0.1119 mL	0.5594 mL	1.1188 mL	5.5938 mL
20 mM	0.0559 mL	0.2797 mL	0.5594 mL	2.7969 mL
50 mM	0.0224 mL	0.1119 mL	0.2238 mL	1.1188 mL
100 mM	0.0112 mL	0.0559 mL	0.1119 mL	0.5594 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MD222MD-222MD 222

MD-222

MD-222

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