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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $789 | Backorder | |
10 mg | $1,360 | Backorder | |
25 mg | $2,860 | Backorder |
Description | MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2]. |
In vitro | MD-222 (1-30 nM; 1-2 hours) treatment effectively reduces MDM2 protein levels and increases p53 levels in a time- and dose-dependent manner in RS4;11 and RS4;11/IRMI-2 cells[1]. MD-222 (30-100 nM; 6 hours) increases the expression of p53-targeted genes, including MDM2, CDKN1A, and PUMA in RS4;11 cells, indicating strong p53 activation[2]. MD-222 (4 days) inhibits cell growth in RS4;11 cells with an IC50 of 5.5 nM, but shows no effect on RS4;11/IRMI-2, MDA-MB-231, and MDA-MB-468 cells[1]. |
Molecular Weight | 893.84 |
Formula | C48H47Cl2FN6O6 |
Cas No. | 2136246-72-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 200 mg/mL (223.76 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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