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Methylproamine

Name: Methylproamine
Brand: TargetMol
SKU: T12019
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Methylproamine is a DNA-binding radioprotector that acts by repairing transient radiation-induced oxidative species on DNA.

Catalog No. T12019Cas No. 188247-01-0

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Purity:98.73%

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COA HNMR HPLC

Methylproamine

Catalog No. T12019Cas No. 188247-01-0

Methylproamine is a DNA-binding radioprotector that acts by repairing transient radiation-induced oxidative species on DNA.

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$48	In Stock
10 mg	$73	In Stock
25 mg	$115	In Stock
50 mg	$163	In Stock
100 mg	$247	In Stock

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Product Introduction

Bioactivity

Description

Methylproamine is a DNA-binding radioprotector that acts by repairing transient radiation-induced oxidative species on DNA.

In vitro

Immunocytochemical methods were used to measure the accumulation of phosphorylated H2AX (γH2AX) foci following ionizing radiation (IR) in patient-derived lymphoblastoid cells exposed to methylproamine. Pulsed field gel electrophoresis DNA damage and repair assays were performed to directly interrogate the action of methylproamine on DNA in irradiated cells.Methylproamine-treated cells had fewer γH2AX foci after IR compared to untreated cells. Also, the presence of methylproamine decreased the amount of lower molecular weight DNA entering the gel[2].

Chemical Properties

Molecular Weight	465.59
Formula	C₂₈H₃₁N₇
Cas No.	188247-01-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (118.13 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1478 mL	10.7391 mL	21.4781 mL	107.3906 mL
5 mM	0.4296 mL	2.1478 mL	4.2956 mL	21.4781 mL
10 mM	0.2148 mL	1.0739 mL	2.1478 mL	10.7391 mL
20 mM	0.1074 mL	0.5370 mL	1.0739 mL	5.3695 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL	2.1478 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0739 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorRadioprotectorDNA/RNA SynthesisMethylproamineinhibitDNA double-strand