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ML204 hydrochloride
🥰Excellent
Catalog No. T24481Cas No. 2070015-10-8
Alias ML204 HCl
ML204 hydrochloride (ML204 HCl) is a selective and potent TRPC4/TRPC5 channel antagonist that blocks TRPC4β currents activated by intracellular dialysis via μ-opioid receptor stimulation or guanosine 5'-3-O-(thio)trisphosphate (GTPgammaS).
ML204 hydrochloride
🥰Excellent
Catalog No. T24481Alias ML204 HClCas No. 2070015-10-8
ML204 hydrochloride (ML204 HCl) is a selective and potent TRPC4/TRPC5 channel antagonist that blocks TRPC4β currents activated by intracellular dialysis via μ-opioid receptor stimulation or guanosine 5'-3-O-(thio)trisphosphate (GTPgammaS).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $49 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ML204 hydrochloride (ML204 HCl) is a selective and potent TRPC4/TRPC5 channel antagonist that blocks TRPC4β currents activated by intracellular dialysis via μ-opioid receptor stimulation or guanosine 5'-3-O-(thio)trisphosphate (GTPgammaS). |
| Targets&IC50 | TRPC4β-mediated increase in intracellular Ca²⁺:0.96 μM |
| In vitro | ML204 hydrochloride inhibited TRPC4β-mediated increase in intracellular Ca²⁺ (HEK293 cells) at an IC50 value of 0.96 μM with 19-fold selectivity for muscarinic receptor-activated TRPC6 channels. [1] ML204 hydrochloride inhibits TRPC4β activity by blocking u-opioid, 5HT1A serotonin, Gi/o activation, and M2 muscarinic receptor or endogenous M3-like muscarinic receptor-stimulated Gq/11 pathways. [2] ML204 hydrochloride Inhibits LPS-induced TRPC5 channel function. [3] |
| In vivo | In an LPS-treated mouse model, ML204 hydrochloride (1 mg/kg; subcutaneous; twice daily for 5 days) increased the risk of death associated with severe hypothermia and decreased the number of peritoneal leukocytes and cytokines. [4] |
| Alias | ML204 HCl |
| Molecular Weight | 262.78 |
| Formula | C15H19ClN2 |
| Cas No. | 2070015-10-8 |
| Smiles | Cl.N=1C=2C=CC=CC2C(=CC1N3CCCCC3)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 20.00 mg/mL (76.11 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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