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Morelloflavone
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Catalog No. TN5515Cas No. 16851-21-1
Alias Fukugetin
Morelloflavone is a biflavonoid derived from Garcinia cambogia with anticancer property that inhibits tumor angiogenesis by targeting Rho GTPases and the extracellular signal-regulated kinase (ERK) signaling pathway. Fukugetin inhibits the cellular proliferation of a variety of cancer cell lines, such as Caspase-9, TNF -α, ER-α, , HER-2.
Morelloflavone
😃Good
Catalog No. TN5515Alias FukugetinCas No. 16851-21-1
Morelloflavone is a biflavonoid derived from Garcinia cambogia with anticancer property that inhibits tumor angiogenesis by targeting Rho GTPases and the extracellular signal-regulated kinase (ERK) signaling pathway. Fukugetin inhibits the cellular proliferation of a variety of cancer cell lines, such as Caspase-9, TNF -α, ER-α, , HER-2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,398 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $1,698 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Morelloflavone is a biflavonoid derived from Garcinia cambogia with anticancer property that inhibits tumor angiogenesis by targeting Rho GTPases and the extracellular signal-regulated kinase (ERK) signaling pathway. Fukugetin inhibits the cellular proliferation of a variety of cancer cell lines, such as Caspase-9, TNF -α, ER-α, , HER-2. |
| In vitro | Methods: HUVEC cells were treated with Morelloflavone (5, 10, 20, 40, 80, 100 μM, 24 hours), PC-3 cells were treated with Morelloflavone (20, 40, 80, 100, 200, 400 μM, 24 hours), and cell viability was determined by MTS method. Results: Morelloflavone significantly inhibited VEGF-induced endothelial cell viability with an IC50 value of 20 μM. Morelloflavone could significantly inhibit normal HUVEC cell viability at a higher concentration with an IC50 value of 80 μM, indicating that Morelloflavone is more effective under angiogenic disease conditions; for PC-3 cells, the IC50 value was greater than 100 μM. [1] |
| In vivo | Methods: Morelloflavone (8 mg/Kg, intraperitoneal injection, 15 days) was used to treat SCID male mice transplanted with prostate cancer cells (PC-3). The mice were scarred, and the tumors were excised and photographed. The tumor sizes of the control and morelloflavone groups were calculated. Results: Morelloflavone strongly inhibited tumor growth in the xenograft mouse prostate tumor model. The effect on mouse body weight was minimal, indicating that the compound had little toxicity at the tested concentrations. [1] |
| Alias | Fukugetin |
| Molecular Weight | 556.47 |
| Formula | C30H20O11 |
| Cas No. | 16851-21-1 |
| Smiles | O=C1[C@H]([C@@H](OC=2C1=C(O)C=C(O)C2)C3=CC=C(O)C=C3)C4=C5C(C(=O)C=C(O5)C6=CC(O)=C(O)C=C6)=C(O)C=C4O |
| Relative Density. | 1.681 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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