N-(3-Aminopropyl)cyclohexylamine, a derivative of cyclohexylamine, acts as a selective and competitive inhibitor of spermine synthase, making it suitable for research on neurological diseases [1].

N-(3-Aminopropyl)cyclohexylamine at concentrations up to 10(-6) M did not affect the neuronal survival, but significantly blocked the survival-promoting effect of spermine (10(-8) M) [1]. APCHA also blocked the spermine-induced promotion of neurite regeneration following axotomy [1]. In primary cultured brain neurons, APCHA works as a spermine antagonist rather than as a spermine synthesis inhibitor [1].