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N-Desethyl Sunitinib
😃Good
Catalog No. T12145Cas No. 356068-97-8
Alias SU-11662
N-Desethyl Sunitinib (SU-11662) is a sunitinib metabolite.
N-Desethyl Sunitinib
😃Good
Catalog No. T12145Alias SU-11662Cas No. 356068-97-8
N-Desethyl Sunitinib (SU-11662) is a sunitinib metabolite.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $77 | 5 days | |
| 1 mL x 10 mM (in DMSO) | $152 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | N-Desethyl Sunitinib (SU-11662) is a sunitinib metabolite. |
| In vitro | Sunitinib inhibits phosphorylation of wild-type FLT3, FLT3-ITD, and FLT3-Asp835 with IC50 of 250 nM, 50 nM, and 30 nM, respectively. Sunitinib inhibits the proliferation of MV4;11 and OC1-AML5 cells with IC50 of 8 nM and 14 nM, respectively, and induces apoptosis in a dose-dependent manner[1].Sunitinib also potently inhibits Kit and FLT-3[3]. |
| In vivo | Sunitinib treatment (20 mg/kg/day) dramatically suppresses the growth subcutaneous MV4;11 (FLT3-ITD) xenografts and prolongs survival in the FLT3-ITD bone marrow engraftment model[1]. |
| Alias | SU-11662 |
| Molecular Weight | 370.42 |
| Formula | C20H23FN4O2 |
| Cas No. | 356068-97-8 |
| Relative Density. | 1.265 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (134.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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