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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | N3-PEG3-vc-PAB-MMAE, a drug-linker conjugate designed for Antibody-Drug Conjugates (ADC), features the integration of monomethyl auristatin E (MMAE), a tubulin inhibitor, via a 3-unit polyethylene glycol (PEG) linker. This compound demonstrates significant antitumor activity. |
In vitro | Monomethyl auristatin E (MMAE; SGD-1010), a synthetic derivative of Dolastatin 10, acts as a potent mitotic inhibitor by blocking tubulin polymerization. It is widely used as the cytotoxic component in antibody-drug conjugates (ADCs) for treating various cancers. |
Molecular Weight | 1352.66 |
Formula | C67H109N13O16 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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