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Pack Size | Price | Availability | Quantity |
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100 mg | Inquiry | Backorder | |
500 mg | Inquiry | Backorder |
Description | NAMPT inhibitor-linker 2, a drug-linker conjugate for antibody-drug conjugates (ADCs), comprises an NAMPT inhibitor payload and a linker. When combined with an anti-c-Kit monoclonal antibody to form ADC-4, it demonstrates potent efficacy against c-Kit expressing cell lines, including GIST-T1 and NCI-H526, with IC50 values of <7 pM and 40 pM, respectively. |
In vitro | ADC-4 exhibits potent activity against c-Kit expressing cell lines, including GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively[1]. ADC-4 (0.01 nM-10 nM, 144 hours) inhibits GIST-T1 cell proliferation without affecting the cell cycle[1]. |
In vivo | ADC-4 (20 mg/kg, i.v. for 28 days) is well-tolerated and induces tumor stasis in mice with GIST-T1 cells[1]. |
Molecular Weight | 624.66 |
Formula | C34H33FN6O5 |
Cas No. | 2241014-82-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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