Popular Searches
Diphenyleneiodonium chlorideEpacadostatGilteritinibDinaciclibRo-3306
TargetMol | Star Product
Wikimole
TargetMol | New Product
New Product
TargetMol | Compound Library
Compound Library
Contact Us
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
TOPBioactivityChemical infoStorage&SolubilityCalculator

Nardosinone

🥰Excellent
Catalog No. T6S1740Cas No. 23720-80-1

1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the promotion of PKA and ERK signaling pathway. 3. Nardosinone enhances staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying both the MAP kinase-dependent and -independent signaling pathways of dbcAMP and staurosporine. 4. The enhancement of NGF-induced neurite outgrowth from PC12D cells by Nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC.

Nardosinone

Nardosinone

🥰Excellent
Purity: 99%
Catalog No. T6S1740Cas No. 23720-80-1
1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the promotion of PKA and ERK signaling pathway. 3. Nardosinone enhances staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying both the MAP kinase-dependent and -independent signaling pathways of dbcAMP and staurosporine. 4. The enhancement of NGF-induced neurite outgrowth from PC12D cells by Nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC.
Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$47In Stock
10 mg$73In Stock
25 mg$132In Stock
50 mg$213In Stock
100 mg$313In Stock
1 mL x 10 mM (in DMSO)$52In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "Nardosinone"

Select Batch
Purity:99%
Contact us for more batch information
Resource Download
COA HPLC HNMR
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the
Chemical Properties
Molecular Weight250.33
FormulaC15H22O3
Cas No.23720-80-1
SmilesC[C@@H]1CCC=C2C(=O)C[C@H]3OOC(C)(C)[C@H]3[C@@]12C
Relative Density.1.11 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 46 mg/mL (183.8 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9947 mL19.9736 mL39.9473 mL199.7363 mL
5 mM0.7989 mL3.9947 mL7.9895 mL39.9473 mL
10 mM0.3995 mL1.9974 mL3.9947 mL19.9736 mL
20 mM0.1997 mL0.9987 mL1.9974 mL9.9868 mL
50 mM0.0799 mL0.3995 mL0.7989 mL3.9947 mL
100 mM0.0399 mL0.1997 mL0.3995 mL1.9974 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

substancesPC12Doutgrowth-promotingneuritogenicNeuriteNardosinoneMAPKInhibitorinhibitcells
Related Tags: buy Nardosinone | purchase Nardosinone | Nardosinone cost | order Nardosinone | Nardosinone chemical structure | Nardosinone formula | Nardosinone molecular weight
TargetMol | Logo

Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.