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NCGC 607

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Purity:99.84%

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COA HPLC HNMR

NCGC 607

Catalog No. T8989Cas No. 1462267-07-7

NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).

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Pack Size	Price	Availability
1 mg	$42	In Stock
5 mg	$139	In Stock
10 mg	$222	In Stock
25 mg	$375	In Stock
50 mg	$553	In Stock
100 mg	$789	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock

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Product Introduction

Bioactivity

Description	NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).
In vitro	NCGC607, a small-molecule noninhibitory chaperone of glucocerebrosidase identified by high-throughput screening and medicinal chemistry structure optimization.?This compound successfully chaperoned the mutant enzyme, restored glucocerebrosidase activity and protein levels, and reduced glycolipid storage in both iPSC-derived macrophages and dopaminergic neurons, indicating its potential for treating neuronopathic Gaucher disease.?In addition, NCGC607 reduced α-synuclein levels in dopaminergic neurons from the patients with parkinsonism, suggesting that noninhibitory small-molecule chaperones of glucocerebrosidase may prove useful for the treatment of Parkinson disease.
Alias	NCGC607

Chemical Properties

Molecular Weight	543.35
Formula	C24H22IN3O4
Cas No.	1462267-07-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (101.22 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8404 mL	9.2022 mL	18.4043 mL	92.0217 mL
5 mM	0.3681 mL	1.8404 mL	3.6809 mL	18.4043 mL
10 mM	0.1840 mL	0.9202 mL	1.8404 mL	9.2022 mL
20 mM	0.0920 mL	0.4601 mL	0.9202 mL	4.6011 mL
50 mM	0.0368 mL	0.1840 mL	0.3681 mL	1.8404 mL
100 mM	0.0184 mL	0.0920 mL	0.1840 mL	0.9202 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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