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Necrostatin 2
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Catalog No. T12203LCas No. 852391-19-6
Alias Necrostatin2
Necrostatin 2 is a necrotic protein and receptor-interacting protein kinase 1 (RIPK1) inhibitor used to study inner ear disorders such as sudden deafness, dizziness and tinnitus.
Necrostatin 2
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Purity: 99.92%
Catalog No. T12203LAlias Necrostatin2Cas No. 852391-19-6
Necrostatin 2 is a necrotic protein and receptor-interacting protein kinase 1 (RIPK1) inhibitor used to study inner ear disorders such as sudden deafness, dizziness and tinnitus.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $57 | In Stock | |
| 2 mg | $78 | In Stock | |
| 5 mg | $166 | 5 days | |
| 1 mL x 10 mM (in DMSO) | $148 | 5 days |
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Purity:99.92%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Necrostatin 2 is a necrotic protein and receptor-interacting protein kinase 1 (RIPK1) inhibitor used to study inner ear disorders such as sudden deafness, dizziness and tinnitus. |
| Targets&IC50 | Jurkat cells (FADD-deficient human ):50 nM(EC50) |
| In vitro | Necrostatin 2 displays activity in a broad range of necroptosis cellular systems. [1] Necrostatin 2 at 30 μM fully protects L929 cells from TNF-α-induced necroptosis. [2] Necrotic apoptosis inhibitory activity was assessed by treating FADD-deficient human Jurkat T cells with TNF-α. Utilizing these conditions the cells efficiently undergo necroptosis, which is completely and selectively inhibited by Necrostatin 2 (EC50=50 nM). [3] |
| Alias | Necrostatin2 |
| Molecular Weight | 277.71 |
| Formula | C13H12ClN3O2 |
| Cas No. | 852391-19-6 |
| Smiles | C(C=1C=2C(NC1)=C(Cl)C=CC2)[C@@H]3C(=O)N(C)C(=O)N3 |
| Relative Density. | 1.450 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL(288.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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