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Necrostatin-34
🥰Excellent
Catalog No. T9095Cas No. 375835-43-1
Alias 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
Necrostatin-34
🥰Excellent
Purity: 98.80%
Catalog No. T9095Alias 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4Cas No. 375835-43-1
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 45 € | In Stock | |
| 5 mg | 112 € | In Stock | |
| 10 mg | 164 € | In Stock | |
| 25 mg | 305 € | In Stock | |
| 50 mg | 441 € | In Stock | |
| 100 mg | 615 € | In Stock | |
| 200 mg | 831 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 130 € | In Stock |
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Purity:98.80%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain. |
| In vitro | Necrostatin-34 (10?μM) inhibits the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation. Necrostatin-34 may block TNFα-induced complex II formation by inhibiting the activation of RIPK1 kinase. Necrostatin-34 shows IC50 values of 667 nM and 134 nM for TNFα in FADD def-Jurkat cells and L939 cells, respectively. |
| Alias | 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 |
| Molecular Weight | 384.48 |
| Formula | C18H16N4O2S2 |
| Cas No. | 375835-43-1 |
| Smiles | Cc1ccc(cc1)C1CC(=O)NC(SCC(=O)Nc2nccs2)=C1C#N |
| Relative Density. | 1.41 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (325.11 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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