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Zharp2-1
🥰Excellent
Catalog No. T79600Cas No. 2772600-18-5
Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-induced peritonitis symptoms in mice, which can be used for the study of inflammatory bowel disease (IBD).
Zharp2-1
🥰Excellent
Purity: 99.41%
Catalog No. T79600Cas No. 2772600-18-5
Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-induced peritonitis symptoms in mice, which can be used for the study of inflammatory bowel disease (IBD).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $62 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $196 | In Stock | |
| 50 mg | $322 | In Stock | |
| 100 mg | $513 | In Stock |
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Purity:99.41%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Zharp2-1, a RIPK2 inhibitor, inhibits the transcription of inflammatory cytokines induced by MDP-induced or Listeria monocytogenes infection and alleviates MDP-induced peritonitis symptoms in mice, which can be used for the study of inflammatory bowel disease (IBD). |
| In vitro | iBMDM from mice were stimulated with 10 ng/mL IFN-γ and pre-treated with Zharp2-1 (IC50=6.4-17.4 nM) for 2 hours, followed by stimulation with 10 μg/mL MDP or 1 μg/mL L18-MDP for 12 hours. The results indicate that Zharp2-1 effectively blocks cytokine transcription and release in human and murine cells induced by MDP. [1]. |
| In vivo | Treatment with Zharp2-1 (15 mg/kg, oral gavage, once daily, for 6 days) protects rats from DNBS-induced colon shortening and colon weight gain, indicating that Zharp2-1 therapy significantly improves colonic mucosal structural damage, muscle thickening, and inflammatory infiltration[1]. |
| Molecular Weight | 383.4 |
| Formula | C19H18N3O2PS |
| Cas No. | 2772600-18-5 |
| Smiles | O=P(C1=CC=2C(=NC=CC2NC=3C=CC=4SC=NC4C3)C=C1OC)(C)C |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (5.22 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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