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Nelonicline
Catalog No. T16281Cas No. 1026134-63-3
Alias ABT-126
Nelonicline is a selective agonist of neuronal nicotinic receptors.
Nelonicline
Catalog No. T16281Alias ABT-126Cas No. 1026134-63-3
Nelonicline is a selective agonist of neuronal nicotinic receptors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Nelonicline is a selective agonist of neuronal nicotinic receptors. |
| In vivo | Nelonicline (0.03 mg/kg) treatment, has no significant effect on LIDs. The effect of Nelonicline (1.0 mg/kg) is also tested for its ability to reduce LIDs at a higher dose of L-dopa (15 mg/kg)/carbidopa (3.75 mg/kg). The higher dose of L-dopa leads to greater LID scores in vehicle-treated monkeys. Nelonicline treatment reduces LIDs by 70%, after the morning dose of L-dopa and 60% after the afternoon dose. The effect of Nelonicline is most pronounced during the latter weeks, possibly because of a greater decline with continued drug treatment. Nelonicline (0.10 mg/kg)treatment, decreases LIDs by ~40%, while the 0.30 and 1.0 mg/kg Nelonicline doses decrease LIDs up to ~60%. These data indicate that Nelonicline would be useful as an antidyskinetic drug in Parkinson's disease. |
| Alias | ABT-126 |
| Molecular Weight | 313.42 |
| Formula | C17H19N3OS |
| Cas No. | 1026134-63-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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