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Neuropeptide W-23(human)

🥰Excellent
Catalog No. TP1073Cas No. 383415-79-0
Alias NPW-23

Neuropeptide W-23(human) (NPW-23) is an endogenous ligand for NPBW1 and NPBW2.

Neuropeptide W-23(human)

Neuropeptide W-23(human)

🥰Excellent
Purity: 98.5%
Catalog No. TP1073Alias NPW-23Cas No. 383415-79-0
Neuropeptide W-23(human) (NPW-23) is an endogenous ligand for NPBW1 and NPBW2.
Pack SizePriceAvailabilityQuantity
1 mg$123In Stock
2 mg$196In Stock
5 mg$372In Stock
10 mg$538In Stock
25 mg$855In Stock
50 mg$1,150In Stock
100 mg$1,550In Stock
500 mg$2,970In Stock
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Purity:98.5%
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Product Introduction

Bioactivity
Description
Neuropeptide W-23(human) (NPW-23) is an endogenous ligand for NPBW1 and NPBW2.
In vitro
NPW-23 increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7 which may involve in the development of vascular hypertension. NPW-23 increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC[1].
In vivo
NPW-23 increases pressure-induced vasotone of the rat mesenteric arteries. Importantly, the expression of NPW is decreased in the hypertensive rats[1]. NPW-23 (0.3 nmol, 1.0 nmol, and 3.0 nmol) induces significant increases in mean arterial pressure (MAP) in conscious, freely moving male rats. Rats that receive either 1.0 or 3.0 nmol NPW-23 demonstrate a significant increase in total activity, ambulatory activity, and duration of stereotypy. NPW-23 fails to elevate MAP in rats pretreated with phentolamine. NPW-23-induced increases in total activity, ambulatory activity, and duration of stereotypy are reduced significantly by pretreatment with the orexin type 1 receptor (OX1R) antagonist, SB-408124 which suggests that orexin neurons are downstream targets of NPW [2].
AliasNPW-23
Chemical Properties
Molecular Weight2584.01
FormulaC119H183N35O28S
Cas No.383415-79-0
SmilesC([C@@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(O)=O)=O)=O)CCSC)=O)CC(C)C)=O)CC(C)C)=O)=O)C)=O)C)=O)CCCNC(=N)N)=O)=O)[C@@H](C)C)=O)[C@@H](C)O)=O)=O)=O)CCCNC(=N)N)=O)CCC3)CO)=O)C)=O)[C@H](C)C)=O)=O)CCCCN)=O)=O)N)C=6C=7C(NC6)=CC=CC7
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: Soluble

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Keywords

NPW23NPW 23NPBW2NPBW1Neuropeptide W23(human)Neuropeptide W-23 (human)Neuropeptide W-23Neuropeptide W 23(human)Neuropeptide WInhibitorinhibithypetensionGPR8GPR7anorexigenic effect
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