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NLRP3-IN-17
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NLRP3-IN-17
Catalog No. T78168Cas No. 2254432-75-0
NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome with an IC50 of 7 nM, effectively inhibiting NLRP3-dependent IL-1β secretion in mice, making it valuable for chronic inflammatory disease research [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $140 | 5 days |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome with an IC50 of 7 nM, effectively inhibiting NLRP3-dependent IL-1β secretion in mice, making it valuable for chronic inflammatory disease research [1]. |
| Targets&IC50 | NLRP3 inflammasome:7 nM |
| In vivo | NLRP3-IN-17 (compound 15) administered orally at 3 mg/kg demonstrated favorable pharmacokinetic (PK) data, with an area under the curve (AUC), half-life (t 1/2), and bioavailability (F%) of 4.2 μg.h/mL, 2.91 h, and 56%, respectively [1]. At a single oral dose of 10 mg/kg, it significantly inhibited NLRP3-dependent IL-1β secretion, reducing IL-1β levels by 44% in an acute in vivo LPS+ATP stimulation model in female C57BL/6 mice [1]. |
| Molecular Weight | 394.49 |
| Formula | C21H22N4O2S |
| Cas No. | 2254432-75-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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