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NLRP3-IN-17
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Catalog No. T78168Cas No. 2254432-75-0
NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome with an IC50 of 7 nM, effectively inhibiting NLRP3-dependent IL-1β secretion in mice, making it valuable for chronic inflammatory disease research [1].
NLRP3-IN-17
😃Good
Catalog No. T78168Cas No. 2254432-75-0
NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome with an IC50 of 7 nM, effectively inhibiting NLRP3-dependent IL-1β secretion in mice, making it valuable for chronic inflammatory disease research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $140 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NLRP3-IN-17 is a potent, selective, and orally active inhibitor of the NLRP3 inflammasome with an IC50 of 7 nM, effectively inhibiting NLRP3-dependent IL-1β secretion in mice, making it valuable for chronic inflammatory disease research [1]. |
| Targets&IC50 | NLRP3 inflammasome:7 nM |
| In vivo | NLRP3-IN-17 (compound 15) administered orally at 3 mg/kg demonstrated favorable pharmacokinetic (PK) data, with an area under the curve (AUC), half-life (t 1/2), and bioavailability (F%) of 4.2 μg.h/mL, 2.91 h, and 56%, respectively [1]. At a single oral dose of 10 mg/kg, it significantly inhibited NLRP3-dependent IL-1β secretion, reducing IL-1β levels by 44% in an acute in vivo LPS+ATP stimulation model in female C57BL/6 mice [1]. |
| Molecular Weight | 394.49 |
| Formula | C21H22N4O2S |
| Cas No. | 2254432-75-0 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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