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Nocloprost
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Catalog No. T33710Cas No. 79360-43-3
Alias ZK94726, ZK84726, ZK 94726, ZK 84726, SH475, SH 475
Nocloprost (SH 475) is a prostaglandin E2 (PGE2) analog, an EP1 and EP3 receptor agonist with local gastric protection and ulcer healing activity, reducing aspirin-induced gastrointestinal lesions, and inducing platelet activation, useful for studying cardiovascular diseases.
Nocloprost
😃Good
Catalog No. T33710Alias ZK94726, ZK84726, ZK 94726, ZK 84726, SH475, SH 475Cas No. 79360-43-3
Nocloprost (SH 475) is a prostaglandin E2 (PGE2) analog, an EP1 and EP3 receptor agonist with local gastric protection and ulcer healing activity, reducing aspirin-induced gastrointestinal lesions, and inducing platelet activation, useful for studying cardiovascular diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $153 | 35 days | |
| 500 μg | $415 | 35 days | |
| 1 mg | $590 | 35 days |
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Concentration:1.0 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | Nocloprost (SH 475) is a prostaglandin E2 (PGE2) analog, an EP1 and EP3 receptor agonist with local gastric protection and ulcer healing activity, reducing aspirin-induced gastrointestinal lesions, and inducing platelet activation, useful for studying cardiovascular diseases. |
| In vitro | In platelet-rich citrate plasma, Nocloprost (> 0.1 mumol/l) causes aggregation of biphasic processes at higher concentrations. Nocloprost activation of platelets is accompanied by thromboxen A2 formation and an increase in cytoplasmic calcium in platelets containing Indo 1. Nocloprost(0.1 μM/L) enhanced aggregation induced by low concentrations of ADP or adrenaline. [2] |
| In vivo | Nocloprost (0.01-100 μg/kg, intragastric administration) is dose-dependent in preventing the formation of gastric lesions. Nocloprost (0.01-100 μg/kg, gavage) did not affect gastric acid secretion or intestinal secretion in rats, but prevented the increase of gastroduodenal alkaline secretion. [1] |
| Alias | ZK94726, ZK84726, ZK 94726, ZK 84726, SH475, SH 475 |
| Molecular Weight | 400.98 |
| Formula | C22H37ClO4 |
| Cas No. | 79360-43-3 |
| Smiles | C(=C/[C@H](C(CCCC)(C)C)O)\[C@@H]1[C@@H](C/C=C\CCCC(O)=O)[C@H](Cl)C[C@H]1O |
| Relative Density. | 1.1g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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