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Noladin ether
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Catalog No. T38007Cas No. 222723-55-9
Alias 2-arachidonyl glyceryl ether, 2-AG ether
Noladin ether (2-AG ether) is a selective and potent cannabinoid CB1 receptor agonist, reducing sensory nerve transmission in rat mesenteric artery beds through a non-CB1/CB2 G(i/o) receptor pathway in a concentration-dependent manner.
Noladin ether
😃Good
Catalog No. T38007Alias 2-arachidonyl glyceryl ether, 2-AG etherCas No. 222723-55-9
Noladin ether (2-AG ether) is a selective and potent cannabinoid CB1 receptor agonist, reducing sensory nerve transmission in rat mesenteric artery beds through a non-CB1/CB2 G(i/o) receptor pathway in a concentration-dependent manner.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $93 | 35 days | |
| 5 mg | $378 | 35 days | |
| 10 mg | $693 | 35 days | |
| 25 mg | $1,430 | 35 days |
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Concentration:10.0 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | Noladin ether (2-AG ether) is a selective and potent cannabinoid CB1 receptor agonist, reducing sensory nerve transmission in rat mesenteric artery beds through a non-CB1/CB2 G(i/o) receptor pathway in a concentration-dependent manner. |
| Targets&IC50 | CB2:>3 mM (Ki), CB1:21.2 nM (Ki) |
| In vitro | In the porcine anterior segment perfusion organ culture model, Noladin ether (3, 30, 300 nM) treatment resulted in a dependent increase in the concentration of aqueous outflow facilities. Treatment of trabecular reticulum cells with Noladin ether (30 nM) can activate p42/44 MAP kinase, and cause the trabecular reticulum cells to become round, actin stress fibers to decrease, and adhesion plaques to decrease. [1] |
| In vivo | Intraperitoneal injection of Noladin ether (0.5, 1.0, and 2.0 mg/kg) in male rats increased food intake dose-dependently by affecting CB (1) receptors. [2] |
| Alias | 2-arachidonyl glyceryl ether, 2-AG ether |
| Molecular Weight | 364.56 |
| Formula | C23H40O3 |
| Cas No. | 222723-55-9 |
| Smiles | C(OCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)(CO)CO |
| Relative Density. | 0.948 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble) DMSO: 8 mg/mL (21.94 mM), Sonication is recommended. DMF: 8 mg/mL (21.94 mM), Sonication is recommended. PBS (pH 7.2): < 1 mg/mL (insoluble) Ethanol:PBS(pH 7.2) (1:1): 500 μg/mL | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/DMF
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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