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OGT 2115

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Purity:97.21%

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COA HNMR HPLC

OGT 2115

Catalog No. T16380Cas No. 853929-59-6

OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 µM), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc). OGT 2115 also showed antiangiogenic properties (IC50=1 μM).

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Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$70	In Stock
10 mg	$125	In Stock
25 mg	$272	In Stock
50 mg	$455	In Stock
100 mg	$672	In Stock

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Product Introduction

Bioactivity

Description	OGT 2115 is an inhibitor of heparanase (IC50 = 0.4 µM), an enzyme that cleaves heparan sulfate into glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc). OGT 2115 also showed antiangiogenic properties (IC50=1 μM).
In vitro	OGT 2115 obviously inhibits the invasion and migration induced by Adriamycin. Furthermore, the MTT assay results display that OGT 2115 does not decrease the anti-proliferative effect of Adriamycin. Heparanase InhibitorOGT 2115 can inhibit metastasis induced by endoplasmic reticulum (ER) stress in breast cancer cells, although not significantly. The number and rate of migrated cells are significantly reduced following the exposure of the cells to Tunicamycin + OGT 2115, compared with the control group [2].
In vivo	OGT 2115 displays a plasma concentration of ~10x the heparanase IC50 following oral dosing at 20 mg/kg when administered to mice[1].

Chemical Properties

Molecular Weight	495.3
Formula	C24H16BrFN2O4
Cas No.	853929-59-6

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility Information	DMSO: 1 mg/ml

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