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OGT-IN-2

Name: OGT-IN-2
Brand: TargetMol
SKU: T9711
Price: -1 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T9711Cas No. 442665-87-4

OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1].

OGT-IN-2

Purity: 99.07%

Catalog No. T9711Cas No. 442665-87-4

Pack Size	Price	Availability
1 mg	$68	In Stock
2 mg	$97	In Stock
5 mg	$168	In Stock
10 mg	$249	In Stock
25 mg	Inquiry	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$185	In Stock

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Purity:99.07%

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COA LCMS

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Product Introduction

Bioactivity

Description	OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1].
Targets&IC50	sOGT:30 μM, ncOGT:53 μM

Chemical Properties

Molecular Weight	446.99
Formula	C₂₃H₂₇ClN₂O₃S
Cas No.	442665-87-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (279.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2372 mL	11.1859 mL	22.3719 mL	111.8593 mL
5 mM	0.4474 mL	2.2372 mL	4.4744 mL	22.3719 mL
10 mM	0.2237 mL	1.1186 mL	2.2372 mL	11.1859 mL
20 mM	0.1119 mL	0.5593 mL	1.1186 mL	5.5930 mL
50 mM	0.0447 mL	0.2237 mL	0.4474 mL	2.2372 mL
100 mM	0.0224 mL	0.1119 mL	0.2237 mL	1.1186 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

OGTmono- acylglycerol acyltransferasearticular diseasesInhibitorarticular cartilageAcyltransferaseinhibitacyl-CoA:cholesterol acyltransferaseDiglyceride acyltransferaseOGT-IN-2OGT IN 2OGTIN2osteoarthritisDiacylglycerol acyltransferase