Powder: -20°C for 3 years | In solvent: -80°C for 1 year
p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 41.00 | |
50 mg | In stock | $ 57.00 | |
100 mg | In stock | $ 74.00 | |
500 mg | In stock | $ 93.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | p-Hydroxycinnamic acid (NSC-59260) can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively. |
Targets&IC50 | thromboxane B2:371 μM, prostaglandin E2:126 μM |
In vitro | p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55?2 (SE 4?01) % and 35?6 (SE 2?35) % relative to the basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary hemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively)[1]. |
Source |
Synonyms | p-Coumaric acid, p-Cumaric acid, p-Hydroxy-cinnamic acid, NSC 59260 |
Molecular Weight | 164.16 |
Formula | C9H8O3 |
CAS No. | 7400-08-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 201 mM
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p-Hydroxycinnamic acid 7400-08-0 GPCR/G Protein Immunology/Inflammation Metabolism Proteases/Proteasome Thrombin Prostaglandin Receptor Endogenous Metabolite Inhibitor p Hydroxycinnamic acid NSC-59260 p-Coumaric acid NSC59260 pHydroxycinnamic acid inhibit p-Cumaric acid p-Hydroxy-cinnamic acid NSC 59260 inhibitor