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p38 MAPK-IN-1

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Catalog No. T16424Cas No. 1006378-90-0

p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, long duration, and low clearance, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.

p38 MAPK-IN-1

p38 MAPK-IN-1

😃Good
Catalog No. T16424Cas No. 1006378-90-0
p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, long duration, and low clearance, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.
Pack SizePriceAvailabilityQuantity
2 mg$1988-10 weeks
5 mg$347In Stock
25 mg$1,1408-10 weeks
50 mg$1,4908-10 weeks
100 mg$1,9908-10 weeks
1 mL x 10 mM (in DMSO)$3828-10 weeks
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Product Introduction

Bioactivity
Description
p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, long duration, and low clearance, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.
Targets&IC50
p38 MAPK:68 nM
In vivo
Methods: p38 MAPK-IN-1 (1 mg/kg, intravenous injection and; 10 mg/kg, oral administration) was administered to male wistar rats for in vivo pharmacokinetic study.
Results: p38 MAPK-IN-1 had a t1/2 of 7.4 hours and an intravenous CL of 2.7 mL/min/kg. The Cmax of p38 MAPK-IN-1 in male wistar rats after oral administration was 5.3 μM. [1]
Chemical Properties
Molecular Weight348.35
FormulaC21H14F2N2O
Cas No.1006378-90-0
SmilesO=N=1C=CC=2C(=NC=CC2C=3C=CC(F)=CC3F)C1C=4C=CC=CC4C
Relative Density.1.27 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (57.41 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8707 mL14.3534 mL28.7068 mL143.5338 mL
5 mM0.5741 mL2.8707 mL5.7414 mL28.7068 mL
10 mM0.2871 mL1.4353 mL2.8707 mL14.3534 mL
20 mM0.1435 mL0.7177 mL1.4353 mL7.1767 mL
50 mM0.0574 mL0.2871 mL0.5741 mL2.8707 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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