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p38 MAPK-IN-1
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Catalog No. T16424Cas No. 1006378-90-0
p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, long duration, and low clearance, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.
p38 MAPK-IN-1
😃Good
Catalog No. T16424Cas No. 1006378-90-0
p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, long duration, and low clearance, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $198 | 8-10 weeks | |
| 5 mg | $347 | In Stock | |
| 25 mg | $1,140 | 8-10 weeks | |
| 50 mg | $1,490 | 8-10 weeks | |
| 100 mg | $1,990 | 8-10 weeks | |
| 1 mL x 10 mM (in DMSO) | $382 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, long duration, and low clearance, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production. |
| Targets&IC50 | p38 MAPK:68 nM |
| In vivo | Methods: p38 MAPK-IN-1 (1 mg/kg, intravenous injection and; 10 mg/kg, oral administration) was administered to male wistar rats for in vivo pharmacokinetic study. Results: p38 MAPK-IN-1 had a t1/2 of 7.4 hours and an intravenous CL of 2.7 mL/min/kg. The Cmax of p38 MAPK-IN-1 in male wistar rats after oral administration was 5.3 μM. [1] |
| Molecular Weight | 348.35 |
| Formula | C21H14F2N2O |
| Cas No. | 1006378-90-0 |
| Smiles | O=N=1C=CC=2C(=NC=CC2C=3C=CC(F)=CC3F)C1C=4C=CC=CC4C |
| Relative Density. | 1.27 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (57.41 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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