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p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, long duration, and low clearance, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $198 | 8-10 weeks | |
5 mg | $347 | In Stock | |
25 mg | $1,140 | 8-10 weeks | |
50 mg | $1,490 | 8-10 weeks | |
100 mg | $1,990 | 8-10 weeks | |
1 mL x 10 mM (in DMSO) | $382 | 8-10 weeks |
Description | p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, long duration, and low clearance, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production. |
Targets&IC50 | p38 MAPK:68 nM |
In vivo | Methods: p38 MAPK-IN-1 (1 mg/kg, intravenous injection and; 10 mg/kg, oral administration) was administered to male wistar rats for in vivo pharmacokinetic study. Results: p38 MAPK-IN-1 had a t1/2 of 7.4 hours and an intravenous CL of 2.7 mL/min/kg. The Cmax of p38 MAPK-IN-1 in male wistar rats after oral administration was 5.3 μM. [1] |
Molecular Weight | 348.35 |
Formula | C21H14F2N2O |
Cas No. | 1006378-90-0 |
Smiles | O=N=1C=CC=2C(=NC=CC2C=3C=CC(F)=CC3F)C1C=4C=CC=CC4C |
Relative Density. | 1.27 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 20 mg/mL (57.41 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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