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PARPi-FL
🥰Excellent
Catalog No. T24597Cas No. 1380359-84-1
Alias PARPiFL, Olaparib-bodipy FL
PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer.
PARPi-FL
🥰Excellent
Purity: 99.73%
Catalog No. T24597Alias PARPiFL, Olaparib-bodipy FLCas No. 1380359-84-1
PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $655 | In Stock | |
| 5 mg | $1,390 | In Stock | |
| 10 mg | $1,880 | In Stock | |
| 25 mg | $2,790 | In Stock | |
| 50 mg | $3,770 | In Stock |
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Purity:99.73%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer. |
| In vitro | The IC50 of PARPi-FL for glioblastoma cell lines U87 and U251 was 27.7 ± 1.3 μM and 8.0 ± 1.2 μM, respectively. [1] |
| In vivo | PARPi-FL has a half-life of 24.5 minutes t1/2 in mice. PARPi-FL (2.5 mg/kg) 90 minutes after intravenous administration, the concentration of PARPi-FL in tumors was significantly higher than in muscle or brain, indicating that PARPi-FL was able to generate high-contrast images of tumor tissue in the brain. [1] PARPi-FL can be used for fluorescent-guided tumor resection in a mouse model of oral cancer. [2] |
| Alias | PARPiFL, Olaparib-bodipy FL |
| Molecular Weight | 640.46 |
| Formula | C34H32BF3N6O3 |
| Cas No. | 1380359-84-1 |
| Smiles | O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCC4=CC=C5C=C6C(C)=CC(C)=[N+]6[B-](F)(N54)F)=O)=O)=C2)F)C7=C1C=CC=C7 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (62.46 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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