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PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $655 | In Stock | |
5 mg | $1,390 | In Stock | |
10 mg | $1,880 | In Stock | |
25 mg | $2,790 | In Stock | |
50 mg | $3,770 | In Stock |
Description | PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer. |
In vitro | The IC50 of PARPi-FL for glioblastoma cell lines U87 and U251 was 27.7 ± 1.3 μM and 8.0 ± 1.2 μM, respectively. [1] |
In vivo | PARPi-FL has a half-life of 24.5 minutes t1/2 in mice. PARPi-FL (2.5 mg/kg) 90 minutes after intravenous administration, the concentration of PARPi-FL in tumors was significantly higher than in muscle or brain, indicating that PARPi-FL was able to generate high-contrast images of tumor tissue in the brain. [1] PARPi-FL can be used for fluorescent-guided tumor resection in a mouse model of oral cancer. [2] |
Alias | PARPiFL, Olaparib-bodipy FL |
Molecular Weight | 640.46 |
Formula | C34H32BF3N6O3 |
Cas No. | 1380359-84-1 |
Smiles | O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCC4=CC=C5C=C6C(C)=CC(C)=[N+]6[B-](F)(N54)F)=O)=O)=C2)F)C7=C1C=CC=C7 |
Relative Density. | no data available |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (62.46 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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