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PARPi-FL

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Catalog No. T24597Cas No. 1380359-84-1
Alias PARPiFL, Olaparib-bodipy FL

PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer.

PARPi-FL

PARPi-FL

🥰Excellent
Purity: 99.73%
Catalog No. T24597Alias PARPiFL, Olaparib-bodipy FLCas No. 1380359-84-1
PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer.
Pack SizePriceAvailabilityQuantity
1 mg$655In Stock
5 mg$1,390In Stock
10 mg$1,880In Stock
25 mg$2,790In Stock
50 mg$3,770In Stock
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Purity:99.73%
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Product Introduction

Bioactivity
Description
PARPi-FL (PARPiFL) is a fluorescent PARP1 inhibitor used for imaging glioblastoma and detecting oral cancer.
In vitro
The IC50 of PARPi-FL for glioblastoma cell lines U87 and U251 was 27.7 ± 1.3 μM and 8.0 ± 1.2 μM, respectively. [1]
In vivo
PARPi-FL has a half-life of 24.5 minutes t1/2 in mice.
PARPi-FL (2.5 mg/kg) 90 minutes after intravenous administration, the concentration of PARPi-FL in tumors was significantly higher than in muscle or brain, indicating that PARPi-FL was able to generate high-contrast images of tumor tissue in the brain. [1]
PARPi-FL can be used for fluorescent-guided tumor resection in a mouse model of oral cancer. [2]
AliasPARPiFL, Olaparib-bodipy FL
Chemical Properties
Molecular Weight640.46
FormulaC34H32BF3N6O3
Cas No.1380359-84-1
SmilesO=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCC4=CC=C5C=C6C(C)=CC(C)=[N+]6[B-](F)(N54)F)=O)=O)=C2)F)C7=C1C=CC=C7
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (62.46 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5614 mL7.8069 mL15.6138 mL78.0689 mL
5 mM0.3123 mL1.5614 mL3.1228 mL15.6138 mL
10 mM0.1561 mL0.7807 mL1.5614 mL7.8069 mL
20 mM0.0781 mL0.3903 mL0.7807 mL3.9034 mL
50 mM0.0312 mL0.1561 mL0.3123 mL1.5614 mL

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