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PD 407824

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Purity:98.02%

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COA LCMS

PD 407824

Catalog No. T16446Cas No. 622864-54-4

PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).

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Pack Size	Price	Availability	Quantity
1 mg	$65	In Stock

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Product Introduction

Bioactivity

Description	PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respectively).
In vitro	Inhibiting Wee1 and Chk1 kinases can lead to the disappearance of DNA damage-induced G2 checkpoint. Research findings indicate that PD 407824 selectively acts on CHK1 and WEE1, with IC50 values exceeding 3.4µM and 3.75µM for PKC and Cdk4, respectively[3].
Alias	PD-407824

Chemical Properties

Molecular Weight	328.32
Formula	C20H12N2O3
Cas No.	622864-54-4

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (304.88 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0458 mL	15.2290 mL	30.4581 mL	152.2904 mL
5 mM	0.6092 mL	3.0458 mL	6.0916 mL	30.4581 mL
10 mM	0.3046 mL	1.5229 mL	3.0458 mL	15.2290 mL
20 mM	0.1523 mL	0.7615 mL	1.5229 mL	7.6145 mL
50 mM	0.0609 mL	0.3046 mL	0.6092 mL	3.0458 mL
100 mM	0.0305 mL	0.1523 mL	0.3046 mL	1.5229 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc