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ZNL 02-096

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Purity:99.84%

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COA FNMR HNMR HPLC LCMS

ZNL 02-096

Catalog No. T41163Cas No. 2414418-49-6

ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL 02-096 induces degradation of Wee1 and accumulation of DNA damage in MOLT-4 cells in vitro, In vitro in MOLT-4 cells, ZNL 02-096 induced Wee1 degradation, accumulation of DNA damage, cell cycle arrest in G2/M phase and apoptosis.ZNL 02-096 showed anti-proliferative effects in 300 cancer cell lines.

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Pack Size	Price	Availability
1 mg	$263	In Stock
2 mg	$392	In Stock
5 mg	$668	In Stock
10 mg	$892	In Stock
25 mg	$1,350	In Stock
50 mg	$1,820	In Stock
100 mg	$2,450	In Stock

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Product Introduction

Bioactivity

Description	ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL 02-096 induces degradation of Wee1 and accumulation of DNA damage in MOLT-4 cells in vitro, In vitro in MOLT-4 cells, ZNL 02-096 induced Wee1 degradation, accumulation of DNA damage, cell cycle arrest in G2/M phase and apoptosis.ZNL 02-096 showed anti-proliferative effects in 300 cancer cell lines.
In vitro	ZNL 02-096 (1 nM-10 μM; 24, 48, and 72 h; OVCAR8, COV362, and Kuramochi cells) induces CRBN-dependent anti-proliferative effects and synergizes with Olaparib. ZNL 02-096 (6 h) degrades Wee1 in OVCAR8 cells, with maximal degradation observed at a 100 nM treatment.[1] ZNL 02-096 (100 nM; 24 h) induces DNA damage, apoptosis, and deregulation of the G2/M checkpoint.[1]
Alias	Pomalidomide-C3-adavosertib

Chemical Properties

Molecular Weight	799.88
Formula	C42H45N11O6
Cas No.	2414418-49-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (62.51 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2502 mL	6.2509 mL	12.5019 mL	62.5094 mL
5 mM	0.2500 mL	1.2502 mL	2.5004 mL	12.5019 mL
10 mM	0.1250 mL	0.6251 mL	1.2502 mL	6.2509 mL
20 mM	0.0625 mL	0.3125 mL	0.6251 mL	3.1255 mL
50 mM	0.0250 mL	0.1250 mL	0.2500 mL	1.2502 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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