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ZN-c3
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Catalog No. T9643Cas No. 2376146-48-2
Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties.[1]
ZN-c3
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Purity: 99.80%
Catalog No. T9643Cas No. 2376146-48-2
Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties.[1]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $97 | In Stock | |
| 5 mg | $239 | In Stock | |
| 10 mg | $372 | In Stock | |
| 25 mg | $689 | In Stock | |
| 50 mg | $1,090 | In Stock | |
| 100 mg | $1,630 | In Stock | |
| 200 mg | $2,190 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $277 | In Stock |
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Purity:99.80%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties.[1] |
| In vitro | METHODS: Azenosertib (ZN-c3) was used to treat cancer cells H23 for three days and A427 for four days, and the proliferation of cancer cells was observed. RESULTS Azenosertib (ZN-c3) inhibited the proliferation of cancer cells H23 and A427, with IC50 of 103 and 75 nM. [1] |
| In vivo | The pharmacokinetic data of Azenosertib (10 mg/kg, oral) showed that the plasma exposure rate of Azenosertib in the beagle dog model was Cmax = 2.1 μM, the half-life T1/2 was 2.3 h, the AUC0-24 h was 9.7 μM·h, and the oral availability was F=142%; Azenosertib (80 mg/kg, oral for 28 days) inhibited the tumor growth of A427 xenograft tumors in the NOD/SCID mouse model[1] |
| Molecular Weight | 526.63 |
| Formula | C29H34N8O2 |
| Cas No. | 2376146-48-2 |
| Smiles | C(C=C)N1N(C=2C(C1=O)=CN=C(NC3=CC=C(C=C3)N4CCN(C)CC4)N2)C=5N=C6C(=CC5)CC[C@@]6(CC)O |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (94.94 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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