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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $229 | In Stock | |
5 mg | $578 | In Stock | |
10 mg | $833 | In Stock | |
25 mg | $1,270 | In Stock | |
50 mg | $1,690 | In Stock | |
100 mg | $2,290 | In Stock | |
1 mL x 10 mM (in DMSO) | $587 | In Stock |
Description | RP-6306 is a potent, selective and orally active PKMYT1 inhibitor (IC50= 14 nM). RP-6306 exhibits a high degree of selectivity for PKMYT1 over other kinases in cellular binding assays. RP-6306 exhibits anticancer effects. |
In vitro | RP-6306 (500 nM; 24h) treatment induced pan-γH2AX in HCC1569 breast cancer cell line indicates that tumor derived CCNE1 amplification also makes cells susceptible to DNA damage induction after PKMYT1 inhibition. RP-6306 treatment can selectively and accidentally activate CDK1 in CCNE1 overexpression cells, thus promoting early mitosis of cells undergoing DNA synthesis [2]. |
In vivo | In the ovarian xenograft model (OVCAR3) amplified by CCNE1, RP-6306 (15, 50, and 300 ppm; oral; daily; for 21 days) significantly reduced tumor growth in OVCAR3 in a dose-dependent manner [1]. |
Alias | (S)-RP-6306 |
Molecular Weight | 324.38 |
Formula | C18H20N4O2 |
Cas No. | 2719793-90-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45.0 mg/mL (138.7 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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