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PD173952
🥰Excellent
Catalog No. T24602Cas No. 305820-75-1
Alias PD-173952, PD 173952
PD173952 is a tyrosine (Src) kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.
PD173952
🥰Excellent
Catalog No. T24602Alias PD-173952, PD 173952Cas No. 305820-75-1
PD173952 is a tyrosine (Src) kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 93 € | In Stock | |
| 5 mg | 244 € | In Stock | |
| 10 mg | 362 € | In Stock | |
| 25 mg | 596 € | In Stock | |
| 50 mg | 843 € | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PD173952 is a tyrosine (Src) kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis. |
| In vitro | METHODS: K562 cells were treated with PD173952 (0.05-1μM, 12 hours), and the protein expression levels of p210Bcr-Abl or CrkL were detected by Western Blot. RESULTS:PD173952 could inhibit the tyrosine phosphorylation of p210 (Bcr-Abl antibody) and CrkL in K562 cells in a concentration-dependent manner. [1] |
| Alias | PD-173952, PD 173952 |
| Molecular Weight | 482.36 |
| Formula | C24H21Cl2N5O2 |
| Cas No. | 305820-75-1 |
| Smiles | O=C1C(=CC=2C=NC(=NC2N1C)NC3=CC=C(C=C3)N4CCOCC4)C5=C(Cl)C=CC=C5Cl |
| Relative Density. | 1.422 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 15 mg/mL（31.10 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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