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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $107 | In Stock | |
5 mg | $263 | In Stock | |
10 mg | $419 | In Stock | |
25 mg | $737 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,420 | In Stock | |
1 mL x 10 mM (in DMSO) | $289 | In Stock |
Description | WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases. |
Targets&IC50 | Wee1:<10 nM |
In vitro | WEE1-IN-3 inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively. ?WEE1 is overexpressed in various cancer types,?WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?ΝΑ repair before mitotic entry.?Normal cells repair damaged DNA during GI arrest.?Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. |
Alias | JUN76288 |
Molecular Weight | 497.59 |
Formula | C28H31N7O2 |
Cas No. | 2272976-28-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 250 mg/mL (502.42 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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