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WEE1-IN-3

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Purity:98.61%

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COA HNMR HPLC

WEE1-IN-3

Catalog No. T8916Cas No. 2272976-28-8

WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.

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Pack Size	Price	Availability
1 mg	$107	In Stock
5 mg	$263	In Stock
10 mg	$419	In Stock
25 mg	$737	In Stock
50 mg	$987	In Stock
100 mg	$1,420	In Stock
1 mL x 10 mM (in DMSO)	$289	In Stock

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Product Introduction

Bioactivity

Description	WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.
Targets&IC50	Wee1:<10 nM
In vitro	WEE1-IN-3 inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively. ?WEE1 is overexpressed in various cancer types,?WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?ΝΑ repair before mitotic entry.?Normal cells repair damaged DNA during GI arrest.?Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair.
Alias	JUN76288

Chemical Properties

Molecular Weight	497.59
Formula	C28H31N7O2
Cas No.	2272976-28-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (502.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0097 mL	10.0484 mL	20.0969 mL	100.4843 mL
5 mM	0.4019 mL	2.0097 mL	4.0194 mL	20.0969 mL
10 mM	0.2010 mL	1.0048 mL	2.0097 mL	10.0484 mL
20 mM	0.1005 mL	0.5024 mL	1.0048 mL	5.0242 mL
50 mM	0.0402 mL	0.2010 mL	0.4019 mL	2.0097 mL
100 mM	0.0201 mL	0.1005 mL	0.2010 mL	1.0048 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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