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PD-149163 hydrochloride
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Catalog No. T70271L
Alias PD-149163 hydrochloride(169528-11-4 Free base), PD149163 hydrochloride
PD-149163 hydrochloride is a neurokinin agonist with antipsychotic activity. It modulates bacterial endotoxin-induced neuroinflammation in mice and can be used in neurological disease research.
PD-149163 hydrochloride
😃Good
Catalog No. T70271LAlias PD-149163 hydrochloride(169528-11-4 Free base), PD149163 hydrochloride
PD-149163 hydrochloride is a neurokinin agonist with antipsychotic activity. It modulates bacterial endotoxin-induced neuroinflammation in mice and can be used in neurological disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $179 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PD-149163 hydrochloride is a neurokinin agonist with antipsychotic activity. It modulates bacterial endotoxin-induced neuroinflammation in mice and can be used in neurological disease research. |
| In vitro | PD-149163 hydrochloride improved lipopolysaccharide (LPS) -induced apoptosis of mouse gastrointestinal tract (GIT) cells in a dose-dependent manner. [2] |
| In vivo | PD-149163 hydrochloride (100-300 μg/kg, intraperitoneal administration) reversed LPS-induced reduction in the thickness of pyramidal cell layers, the number of pyramidal neurons, and structural dislocation, contraction, and damage in the hippocampus of mice. [1] PD-149163 hydrochloride (100-300 μg/kg, intraperitoneal administration) modulated the enteric toxicity of LPS in mice by utilizing its anti-inflammatory, antioxidant, and cell proliferative properties. [2] |
| Alias | PD-149163 hydrochloride(169528-11-4 Free base), PD149163 hydrochloride |
| Molecular Weight | 834.53 |
| Formula | C42H72ClN9O6 |
| Smiles | O=C([C@H]1N(CCC1)C([C@H](CCCCN)NC[C@@H](N)CCCCN)=O)N[C@H](C(N[C@@H](C(C)(C)C)C(N[C@@H](CC(C)C)C(OCC)=O)=O)=O)CC2=CNC3=CC=CC=C23.Cl |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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